Detailed information of TA system TA216948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3195883..3196399
• Replicon: chromosome
• Accession: NZ_CP083633
• Organism: Klebsiella quasipneumoniae strain FDAARGOS_1503

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LA349_RS15450
• Protein ID: WP_044525202.1
• Coordinates: 3196115..3196399 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: LA349_RS15445
• Protein ID: WP_023291757.1
• Coordinates: 3195883..3196125 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA349_RS15430 (3191914)	3191914..3192654	+	741	WP_017900574.1	KDGP aldolase family protein	-
LA349_RS15435 (3192721)	3192721..3193872	+	1152	WP_023291755.1	lactonase family protein	-
LA349_RS15440 (3193895)	3193895..3195805	+	1911	WP_044525201.1	PRD domain-containing protein	-
LA349_RS15445 (3195883)	3195883..3196125	+	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LA349_RS15450 (3196115)	3196115..3196399	+	285	WP_044525202.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LA349_RS15455 (3196403)	3196403..3196867	-	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LA349_RS15460 (3197263)	3197263..3199401	-	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10965.82 Da
• Isoelectric Point: 10.4974

>T216948 WP_044525202.1 NZ_CP083633:3196115-3196399 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWHKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T216948 NZ_CP113535:365061-365336 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT216948 WP_023291757.1 NZ_CP083633:3195883-3196125 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT216948 NZ_CP113535:364798-365058 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86