Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1806813..1807470 Replicon chromosome
Accession NZ_CP083633
Organism Klebsiella quasipneumoniae strain FDAARGOS_1503

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag LA349_RS08685 Protein ID WP_023290968.1
Coordinates 1806813..1807223 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LA349_RS08690 Protein ID WP_002916312.1
Coordinates 1807204..1807470 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA349_RS08665 (1802813) 1802813..1804546 - 1734 WP_044524681.1 single-stranded-DNA-specific exonuclease RecJ -
LA349_RS08670 (1804552) 1804552..1805265 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LA349_RS08675 (1805288) 1805288..1806184 - 897 WP_044524682.1 site-specific tyrosine recombinase XerD -
LA349_RS08680 (1806285) 1806285..1806806 + 522 WP_004205324.1 flavodoxin FldB -
LA349_RS08685 (1806813) 1806813..1807223 - 411 WP_023290968.1 protein YgfX Toxin
LA349_RS08690 (1807204) 1807204..1807470 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LA349_RS08695 (1807716) 1807716..1808699 + 984 WP_044524683.1 tRNA-modifying protein YgfZ -
LA349_RS08700 (1808846) 1808846..1809505 - 660 WP_008806429.1 hemolysin III family protein -
LA349_RS08705 (1809669) 1809669..1809980 - 312 WP_023290970.1 N(4)-acetylcytidine aminohydrolase -
LA349_RS08710 (1810031) 1810031..1810759 + 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
LA349_RS08715 (1810878) 1810878..1812311 + 1434 WP_044524684.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T216947 WP_023290968.1 NZ_CP083633:c1807223-1806813 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T216947 NZ_CP113535:316725-317093 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT216947 WP_002916312.1 NZ_CP083633:c1807470-1807204 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216947 NZ_CP113535:316507-316728 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References