Detailed information of TA system TA021694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 512815..513316
• Replicon: chromosome
• Accession: NC_008346
• Organism: Syntrophomonas wolfei subsp. wolfei str. Goettingen G311

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q0AZT4
• Locus tag: SWOL_RS02215
• Protein ID: WP_011639878.1
• Coordinates: 512815..513069 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q0AZT3
• Locus tag: SWOL_RS02220
• Protein ID: WP_011639879.1
• Coordinates: 513062..513316 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SWOL_RS02185	507903..508673	-	771	WP_011639874.1	CoA activase	-
SWOL_RS02190	509123..509482	+	360	WP_011639875.1	BlaI/MecI/CopY family transcriptional regulator	-
SWOL_RS02195	509493..509786	+	294	WP_041427286.1	hypothetical protein	-
SWOL_RS02200	509823..510128	+	306	WP_041427287.1	hypothetical protein	-
SWOL_RS02205	510125..511000	+	876	WP_155814104.1	IS3 family transposase	-
SWOL_RS13455	511273..512550	+	1278	WP_155814105.1	M56 family metallopeptidase	-
SWOL_RS02215	512815..513069	-	255	WP_011639878.1	Txe/YoeB family addiction module toxin	Toxin
SWOL_RS02220	513062..513316	-	255	WP_011639879.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SWOL_RS02225	513349..513564	-	216	WP_155814106.1	hypothetical protein	-
SWOL_RS02230	513862..514485	+	624	WP_011639881.1	3-hydroxybutyryl-CoA dehydrogenase	-
SWOL_RS02235	514604..515944	+	1341	WP_011639882.1	4-hydroxybutyrate CoA-transferase	-
SWOL_RS02240	516326..517639	+	1314	WP_155814260.1	sigma 54-interacting transcriptional regulator	-
SWOL_RS14630	517723..517866	-	144	WP_173309188.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10264.58 Da
• Isoelectric Point: 10.0241

>T21694 WP_011639878.1 NC_008346:c513069-512815 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
MNKVFTHTAWEEYQYWQKENRKMTSRINELIRDIERNGNTGIGKPEALRHELSGYWSRRINNEHRLIYSIEGKNINIISC
RRHY

Nucleotide

• Length: 255 bp

>T21694 NC_008346:c513069-512815 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
ATGAATAAAGTTTTCACACATACAGCCTGGGAAGAATACCAGTACTGGCAGAAAGAAAATCGCAAAATGACCAGCCGTAT
TAATGAATTAATTAGAGACATTGAACGCAATGGAAACACAGGTATCGGGAAACCGGAAGCGTTAAGACATGAATTGTCCG
GGTACTGGAGCAGAAGAATCAATAATGAGCATAGATTGATATACTCCATTGAAGGGAAAAATATCAATATTATTTCTTGC
CGACGGCATTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9673.95 Da
• Isoelectric Point: 4.6282

>AT21694 WP_011639879.1 NC_008346:c513316-513062 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
MMAVNYSTLRENLKKYCDAANQDLEPIIVTRKNGGNVVLISESEYNNLLENLYIRSDPEYYNKLLKSIEELKSGKTLRSE
LADE

Nucleotide

• Length: 255 bp

>AT21694 NC_008346:c513316-513062 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
ATGATGGCAGTAAACTATTCTACGCTGCGTGAAAACCTGAAAAAATACTGTGATGCGGCTAATCAAGATCTTGAACCAAT
CATTGTTACCAGAAAAAACGGCGGCAATGTAGTGTTAATCTCTGAAAGTGAATACAATAATCTTCTGGAAAATCTCTACA
TCAGGAGCGACCCGGAATATTATAATAAGCTATTGAAGTCGATTGAAGAATTGAAATCAGGAAAAACGCTTCGCTCAGAG
CTTGCCGATGAATAA

Structures

Toxin

• AlphaFold DB: Q0AZT4

Antitoxin

• AlphaFold DB: Q0AZT3