Detailed information of TA system TA216938

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 46206..46731
• Replicon: plasmid unnamed
• Accession: NZ_CP083632
• Organism: Klebsiella quasipneumoniae strain FDAARGOS_1504

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: D4HQE7
• Locus tag: LA339_RS24715
• Protein ID: WP_013023785.1
• Coordinates: 46426..46731 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A9E1GDP8
• Locus tag: LA339_RS24710
• Protein ID: WP_004197642.1
• Coordinates: 46206..46424 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA339_RS24665 (LA339_24665)	41416..42087	+	672	WP_032456798.1	SOS response-associated peptidase	-
LA339_RS24670 (LA339_24670)	42266..42589	+	324	WP_021312689.1	hypothetical protein	-
LA339_RS24675 (LA339_24675)	42830..43606	+	777	WP_060617172.1	DUF2971 domain-containing protein	-
LA339_RS24680 (LA339_24680)	43760..43990	-	231	WP_004213598.1	hypothetical protein	-
LA339_RS24685 (LA339_24685)	44004..44207	-	204	WP_032456799.1	HHA domain-containing protein	-
LA339_RS24690 (LA339_24690)	44268..44762	-	495	WP_004213594.1	hypothetical protein	-
LA339_RS24695 (LA339_24695)	44793..45365	-	573	WP_016240378.1	hypothetical protein	-
LA339_RS24700 (LA339_24700)	45362..45610	-	249	WP_000272716.1	hypothetical protein	-
LA339_RS24705 (LA339_24705)	45809..45997	+	189	Protein_53	hypothetical protein	-
LA339_RS24710 (LA339_24710)	46206..46424	+	219	WP_004197642.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
LA339_RS24715 (LA339_24715)	46426..46731	+	306	WP_013023785.1	type II toxin-antitoxin system toxin CcdB	Toxin
LA339_RS24720 (LA339_24720)	46918..47922	+	1005	WP_032456800.1	hypothetical protein	-
LA339_RS24725 (LA339_24725)	48120..48905	+	786	WP_032456801.1	site-specific integrase	-
LA339_RS24730 (LA339_24730)	48923..49288	-	366	WP_148673529.1	hypothetical protein	-
LA339_RS24735 (LA339_24735)	49827..50582	+	756	WP_001568031.1	replication initiation protein RepE	-
LA339_RS24740 (LA339_24740)	50904..51461	+	558	WP_224222652.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..77601	77601

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11615.30 Da
• Isoelectric Point: 6.4672

>T216938 WP_013023785.1 NZ_CP083632:46426-46731 [Klebsiella quasipneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Nucleotide

• Length: 306 bp

>T216938 NZ_CP113534:1954273-1954376 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8376.34 Da
• Isoelectric Point: 4.7405

>AT216938 WP_004197642.1 NZ_CP083632:46206-46424 [Klebsiella quasipneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Nucleotide

• Length: 219 bp

>AT216938 NZ_CP113534:c1954389-1954235 [Salmonella enterica]
TTTTAATCTAAATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Structures

Toxin

• AlphaFold DB: A0A2J4ZZW6