Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4648535..4649192 Replicon chromosome
Accession NZ_CP083631
Organism Klebsiella quasipneumoniae strain FDAARGOS_1504

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag LA339_RS22270 Protein ID WP_004205323.1
Coordinates 4648782..4649192 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LA339_RS22265 Protein ID WP_002916312.1
Coordinates 4648535..4648801 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA339_RS22240 (4643744) 4643744..4645177 - 1434 WP_032456597.1 6-phospho-beta-glucosidase BglA -
LA339_RS22245 (4645296) 4645296..4646024 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
LA339_RS22250 (4646074) 4646074..4646385 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
LA339_RS22255 (4646548) 4646548..4647207 + 660 WP_004205319.1 hemolysin III family protein -
LA339_RS22260 (4647306) 4647306..4648289 - 984 WP_032456596.1 tRNA-modifying protein YgfZ -
LA339_RS22265 (4648535) 4648535..4648801 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LA339_RS22270 (4648782) 4648782..4649192 + 411 WP_004205323.1 protein YgfX Toxin
LA339_RS22275 (4649199) 4649199..4649720 - 522 WP_004205324.1 flavodoxin FldB -
LA339_RS22280 (4649821) 4649821..4650717 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LA339_RS22285 (4650740) 4650740..4651453 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LA339_RS22290 (4651459) 4651459..4653192 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T216937 WP_004205323.1 NZ_CP083631:4648782-4649192 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T216937 NZ_CP113534:c993528-993001 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT216937 WP_002916312.1 NZ_CP083631:4648535-4648801 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216937 NZ_CP113534:c993815-993525 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References