Detailed information of TA system TA216936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3321998..3322514
• Replicon: chromosome
• Accession: NZ_CP083631
• Organism: Klebsiella quasipneumoniae strain FDAARGOS_1504

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LA339_RS15855
• Protein ID: WP_004206511.1
• Coordinates: 3321998..3322282 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LA339_RS15860
• Protein ID: WP_032456903.1
• Coordinates: 3322272..3322514 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA339_RS15840 (3317040)	3317040..3318695	+	1656	WP_032456905.1	alpha,alpha-phosphotrehalase	-
LA339_RS15845 (3319081)	3319081..3321219	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
LA339_RS15850 (3321530)	3321530..3321994	+	465	WP_032456904.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LA339_RS15855 (3321998)	3321998..3322282	-	285	WP_004206511.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LA339_RS15860 (3322272)	3322272..3322514	-	243	WP_032456903.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LA339_RS15865 (3322592)	3322592..3324502	-	1911	WP_032456902.1	PRD domain-containing protein	-
LA339_RS15870 (3324525)	3324525..3325676	-	1152	WP_017900573.1	lactonase family protein	-
LA339_RS15875 (3325744)	3325744..3326484	-	741	WP_017900574.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11163.01 Da
• Isoelectric Point: 10.4599

>T216936 WP_004206511.1 NZ_CP083631:c3322282-3321998 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCDKIKLKASGYRLVYQVRDRVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T216936 NZ_CP113534:840823-841221 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9002.52 Da
• Isoelectric Point: 5.1088

>AT216936 WP_032456903.1 NZ_CP083631:c3322514-3322272 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPLPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT216936 NZ_CP113534:840596-840823 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA