Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2582907..2583526 Replicon chromosome
Accession NZ_CP083631
Organism Klebsiella quasipneumoniae strain FDAARGOS_1504

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LA339_RS12355 Protein ID WP_002892050.1
Coordinates 2583308..2583526 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LA339_RS12350 Protein ID WP_002892066.1
Coordinates 2582907..2583281 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA339_RS12340 (2578060) 2578060..2579253 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LA339_RS12345 (2579276) 2579276..2582422 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit AcrB -
LA339_RS12350 (2582907) 2582907..2583281 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LA339_RS12355 (2583308) 2583308..2583526 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LA339_RS12360 (2583685) 2583685..2584251 + 567 WP_004204750.1 maltose O-acetyltransferase -
LA339_RS12365 (2584223) 2584223..2584345 - 123 WP_032426076.1 hypothetical protein -
LA339_RS12370 (2584388) 2584388..2584858 + 471 WP_004204751.1 YlaC family protein -
LA339_RS12375 (2584827) 2584827..2586284 - 1458 WP_032455644.1 PLP-dependent aminotransferase family protein -
LA339_RS12380 (2586385) 2586385..2587083 + 699 WP_004204753.1 GNAT family protein -
LA339_RS12385 (2587080) 2587080..2587220 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LA339_RS12390 (2587220) 2587220..2587483 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T216934 WP_002892050.1 NZ_CP083631:2583308-2583526 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T216934 NZ_CP113534:310830-311198 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT216934 WP_002892066.1 NZ_CP083631:2582907-2583281 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT216934 NZ_CP113534:310612-310833 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGACAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References