Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1314913..1316501 Replicon chromosome
Accession NZ_CP083631
Organism Klebsiella quasipneumoniae strain FDAARGOS_1504

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LA339_RS06310 Protein ID WP_032456033.1
Coordinates 1314913..1316235 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LA339_RS06315 Protein ID WP_032456032.1
Coordinates 1316235..1316501 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA339_RS06275 (1309995) 1309995..1310213 + 219 WP_002904808.1 ParD-like family protein -
LA339_RS06280 (1310194) 1310194..1310976 + 783 WP_032456037.1 type I methionyl aminopeptidase -
LA339_RS06285 (1311245) 1311245..1312360 + 1116 WP_032456036.1 serine hydrolase domain-containing protein -
LA339_RS06290 (1312347) 1312347..1312691 + 345 WP_032456035.1 hypothetical protein -
LA339_RS06295 (1312720) 1312720..1313253 + 534 WP_004205916.1 hypothetical protein -
LA339_RS06300 (1313256) 1313256..1313462 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
LA339_RS06305 (1313604) 1313604..1314896 + 1293 WP_032456034.1 glycoside hydrolase family 10 protein -
LA339_RS06310 (1314913) 1314913..1316235 - 1323 WP_032456033.1 type II toxin-antitoxin system HipA family toxin Toxin
LA339_RS06315 (1316235) 1316235..1316501 - 267 WP_032456032.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LA339_RS06320 (1316784) 1316784..1317110 - 327 WP_032456031.1 hydroxyisourate hydrolase -
LA339_RS06325 (1317107) 1317107..1317607 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LA339_RS06330 (1317585) 1317585..1318964 - 1380 WP_032456030.1 nucleobase:cation symporter-2 family protein -
LA339_RS06335 (1319310) 1319310..1320464 + 1155 WP_032456029.1 FAD-dependent urate hydroxylase HpxO -
LA339_RS06340 (1320445) 1320445..1321368 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49039.30 Da        Isoelectric Point: 8.2542

>T216933 WP_032456033.1 NZ_CP083631:c1316235-1314913 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAYLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Download         Length: 1323 bp

>T216933 NZ_CP113534:200930-201415 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10012.45 Da        Isoelectric Point: 6.4538

>AT216933 WP_032456032.1 NZ_CP083631:c1316501-1316235 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLEVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp

>AT216933 NZ_CP113534:200655-200942 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References