Detailed information of TA system TA021693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-DinJ
• Location: 468879..469414
• Replicon: chromosome
• Accession: NC_008346
• Organism: Syntrophomonas wolfei subsp. wolfei str. Goettingen G311

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: Q0AZX4
• Locus tag: SWOL_RS01995
• Protein ID: WP_011639838.1
• Coordinates: 468879..469145 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SWOL_RS02000
• Protein ID: WP_041427278.1
• Coordinates: 469142..469414 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SWOL_RS01975	465059..466558	-	1500	WP_041427273.1	hypothetical protein	-
SWOL_RS01980	466555..467253	-	699	WP_041427275.1	hypothetical protein	-
SWOL_RS01985	467559..468188	+	630	WP_011639836.1	hypothetical protein	-
SWOL_RS01990	468176..468634	+	459	WP_011639837.1	hypothetical protein	-
SWOL_RS01995	468879..469145	-	267	WP_011639838.1	Txe/YoeB family addiction module toxin	Toxin
SWOL_RS02000	469142..469414	-	273	WP_041427278.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SWOL_RS02005	469861..470430	+	570	WP_011639840.1	4Fe-4S dicluster domain-containing protein	-
SWOL_RS02010	470432..471820	+	1389	WP_011639841.1	CoB--CoM heterodisulfide reductase iron-sulfur subunit B family protein	-
SWOL_RS02020	471845..473830	+	1986	WP_155814100.1	CoB--CoM heterodisulfide reductase iron-sulfur subunit A family protein	-
SWOL_RS14175	473821..474252	+	432	WP_155814101.1	hydrogenase iron-sulfur subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10434.90 Da
• Isoelectric Point: 9.5175

>T21693 WP_011639838.1 NC_008346:c469145-468879 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
MKINFTEMGWADYLYWQMQDKKTIKRINQLIKDIERNGSLNGIGRPEPLKGDLTGWCSRRIDDTNRLVYRLRDDSLEIGQ
CRGHYSNK

Nucleotide

• Length: 267 bp

>T21693 NC_008346:c469145-468879 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
ATGAAAATAAACTTTACGGAAATGGGATGGGCGGATTATCTCTATTGGCAAATGCAAGATAAAAAGACGATAAAACGGAT
AAATCAGCTAATAAAGGATATAGAGCGTAATGGCAGCTTAAATGGGATAGGTCGGCCGGAACCTTTAAAGGGGGATTTGA
CTGGGTGGTGCTCACGCAGGATAGATGACACAAACCGCCTTGTTTATCGTCTGCGTGATGATTCTTTGGAAATTGGCCAG
TGTCGAGGACACTACAGTAATAAGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10438.04 Da
• Isoelectric Point: 5.8650

>AT21693 WP_041427278.1 NC_008346:c469414-469142 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
MAKTTNISIRMDKDLKERADAVFNEMGMNMTTAFNIFVRQTLRQGKIPFEIYADPFYGERNMKALHQSIQEAEEGKFVTK
TLDELLAMEK

Nucleotide

• Length: 273 bp

>AT21693 NC_008346:c469414-469142 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
ATGGCTAAAACCACAAATATCAGCATCCGTATGGATAAAGATCTGAAAGAAAGGGCAGACGCAGTGTTTAATGAAATGGG
GATGAACATGACAACAGCTTTTAACATCTTCGTTCGCCAAACTCTACGTCAAGGCAAAATCCCTTTTGAAATCTATGCAG
ACCCATTTTATGGTGAAAGAAACATGAAAGCACTTCACCAATCTATTCAAGAGGCGGAGGAAGGGAAGTTTGTTACAAAA
ACATTGGATGAACTCCTGGCGATGGAAAAATGA

Structures

Toxin

• AlphaFold DB: Q0AZX4