Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5009922..5010582 Replicon chromosome
Accession NZ_CP083630
Organism Leclercia adecarboxylata strain FDAARGOS_1505

Toxin (Protein)


Gene name cptA Uniprot ID A0A7H0FEK5
Locus tag LA332_RS23900 Protein ID WP_032613858.1
Coordinates 5010169..5010582 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G7TIV6
Locus tag LA332_RS23895 Protein ID WP_032613860.1
Coordinates 5009922..5010188 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA332_RS23870 (LA332_23870) 5005041..5006474 - 1434 WP_032613871.1 6-phospho-beta-glucosidase BglA -
LA332_RS23875 (LA332_23875) 5006587..5007318 - 732 WP_032613869.1 MurR/RpiR family transcriptional regulator -
LA332_RS23880 (LA332_23880) 5007371..5007682 + 312 WP_032613867.1 N(4)-acetylcytidine aminohydrolase -
LA332_RS23885 (LA332_23885) 5007848..5008507 + 660 WP_032613865.1 hemolysin III family protein -
LA332_RS23890 (LA332_23890) 5008637..5009617 - 981 WP_032613862.1 tRNA-modifying protein YgfZ -
LA332_RS23895 (LA332_23895) 5009922..5010188 + 267 WP_032613860.1 FAD assembly factor SdhE Antitoxin
LA332_RS23900 (LA332_23900) 5010169..5010582 + 414 WP_032613858.1 protein YgfX Toxin
LA332_RS23905 (LA332_23905) 5010587..5011108 - 522 WP_032613856.1 flavodoxin FldB -
LA332_RS23910 (LA332_23910) 5011210..5012106 + 897 WP_032613854.1 site-specific tyrosine recombinase XerD -
LA332_RS23915 (LA332_23915) 5012132..5012845 + 714 WP_032613852.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LA332_RS23920 (LA332_23920) 5012851..5014584 + 1734 WP_032613850.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16231.98 Da        Isoelectric Point: 10.6531

>T216924 WP_032613858.1 NZ_CP083630:5010169-5010582 [Leclercia adecarboxylata]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLIPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLQWQGS
EWEIIGTPWMLNSGMMLRLRKGDGKRYQHLWLSADSMDEGEWRDLRRMLSQQPTHGR

Download         Length: 414 bp

>T216924 NZ_CP113519:4428733-4429029 [Pseudomonas sp. GOM7]
ATGGCTGAAATAGTCTGGACGAGTCCCGCCCTCGAACAACTCGACGAGCTGGCGCACTACATCGCCCTCGACAAACCCGA
CGCTGCTCGCGCGTTGGTCAGGAAGGTCGTCGAAGCCGTCGCGCGCCTGGCGGAGTCCCCCCTGTCAGGCCGCGCTCCCG
GAGAACTGCCGAACTCCGTGTATCGCGAAATCGTCGTCCCGCCCTGTCGGGTCTTCTACCGCCCGGCAGAGGGCAAGGTG
TTCATCATCCACATCATGCGAGAAGAGCGGGCGCTACGCGCCCACATGCTCGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10539.06 Da        Isoelectric Point: 4.6787

>AT216924 WP_032613860.1 NZ_CP083630:5009922-5010188 [Leclercia adecarboxylata]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKKLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216924 NZ_CP113519:4428488-4428745 [Pseudomonas sp. GOM7]
ATGAAAGTCGAACTGGTCACCAACCTGAAGCGACAAGCCACCAAGATCCTCGCTGACCTTCACGAGTCCAAAGAGCCCGT
GCTGATCACCGAGCATGGAGTGCCCTCGGCCTATCTGGTGGATGTCGATGATTACCAGTTCATGCAGAGGCGCCTCGCCC
TTCTGGATGGCCTGGCCTGCGGTGAACGGGCCGTACTGGAGGGCAATACCCTCAGCCATGAACAGGCCAGGGAACGGCTG
GGCAAATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0FEK5

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7TIV6

References