Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1042950..1043476 Replicon chromosome
Accession NZ_CP083630
Organism Leclercia adecarboxylata strain FDAARGOS_1505

Toxin (Protein)


Gene name relE Uniprot ID A0A855ELU0
Locus tag LA332_RS05055 Protein ID WP_032611731.1
Coordinates 1043189..1043476 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag LA332_RS05050 Protein ID WP_000534858.1
Coordinates 1042950..1043189 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA332_RS05020 (LA332_05020) 1038047..1038349 + 303 WP_032611738.1 hypothetical protein -
LA332_RS05025 (LA332_05025) 1038361..1039359 + 999 WP_051916009.1 tail fiber domain-containing protein -
LA332_RS05030 (LA332_05030) 1039468..1039707 + 240 WP_032611736.1 hypothetical protein -
LA332_RS05035 (LA332_05035) 1039707..1040030 + 324 WP_032611734.1 hypothetical protein -
LA332_RS05040 (LA332_05040) 1040142..1040969 - 828 WP_032611763.1 universal stress protein -
LA332_RS05045 (LA332_05045) 1040987..1042465 - 1479 WP_032611732.1 SulP family inorganic anion transporter -
LA332_RS05050 (LA332_05050) 1042950..1043189 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LA332_RS05055 (LA332_05055) 1043189..1043476 + 288 WP_032611731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LA332_RS05060 (LA332_05060) 1043731..1044330 + 600 WP_246867351.1 hypothetical protein -
LA332_RS05065 (LA332_05065) 1044394..1044544 + 151 Protein_983 hypothetical protein -
LA332_RS05070 (LA332_05070) 1044649..1044815 - 167 Protein_984 transposase -
LA332_RS05075 (LA332_05075) 1045174..1046294 + 1121 Protein_985 IS3 family transposase -
LA332_RS05080 (LA332_05080) 1046340..1046981 - 642 WP_032611729.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 986407..1054106 67699
- flank IS/Tn - - 1045470..1046294 824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11148.22 Da        Isoelectric Point: 10.3898

>T216916 WP_032611731.1 NZ_CP083630:1043189-1043476 [Leclercia adecarboxylata]
MAYLLDFDERALKEWRKLGSTVREQLKKKLAEVLESPRIEVNKLRGMPDCYKIKLKSSGYRLVYQVIDEKVVVFVVSVGK
RERSKVYSEAVKRIL

Download         Length: 288 bp

>T216916 NZ_CP113517:2277092-2277520 [Methylomonas rapida]
ATGATTTTGCTTGATACCAATGTCGTTTCTGAGCCTTTAAAAGCGTCCTGCGATAAAAGCGTACTTTCTTGGATTGATGA
ACAAGTCATCGAAACACTGTACCTCTCGACAATCAGCCTTGCAGAACTGCGTTTTGGTATCGCGGTGCTGCCAGAGGGTA
AACGCAGGGATACTCTCTTTTCCAGCCTAGAGCAGCAAGTTTTACCGTTATTCGCTGGACGCATCCTGCTTTTCGATGAG
TCGGCATCGCAAGCTTATGCAACATTGCGTGCCCGTGCCCGTACTGCTGGACAGGCCATTGCTACTGCAGATGGATATAT
TGCTGCAATTGCTGTGGCGCATGGTTTCGCGGTAGCAACTCGCGATACGTCGCCATTTGAGGCTGTTGGTTTAAAAGTCA
TCAACCCTTGGACGTGGATGGCTCATTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT216916 WP_000534858.1 NZ_CP083630:1042950-1043189 [Leclercia adecarboxylata]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT216916 NZ_CP113517:2276856-2277095 [Methylomonas rapida]
ATGGCGTCTGTCACTGTCCGCAACTTATCTGATGAAACTCATCGCGCCTTGCGTGTGCGTGCCGCTATGCATGGTCATAG
CACAGAAGCTGAAATCAGGGCAATTTTAGATAATACTGTCAGGCCCGATAATCGAATTAAGCTTGGTTCTTTGCTGGCCA
AAATTGGTCTTGAAGTGGGCGGAGTCGATCTTGAGATAGAGCGTGATAAATCGCCTACTGAACCTTTGGATTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855ELU0

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References