Detailed information of TA system TA021691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 4132172..4132743
• Replicon: chromosome
• Accession: NC_008345
• Organism: Shewanella frigidimarina NCIMB 400

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q07XG2
• Locus tag: SFRI_RS17875
• Protein ID: WP_011638897.1
• Coordinates: 4132172..4132483 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q07XG1
• Locus tag: SFRI_RS17880
• Protein ID: WP_011638898.1
• Coordinates: 4132483..4132743 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFRI_RS17870	4129062..4132148	-	3087	WP_011638896.1	Tn3 family transposase	-
SFRI_RS17875	4132172..4132483	-	312	WP_011638897.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SFRI_RS17880	4132483..4132743	-	261	WP_011638898.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SFRI_RS17885	4132936..4133895	-	960	WP_011638899.1	cation diffusion facilitator family transporter	-
SFRI_RS17890	4133915..4134481	-	567	WP_011638900.1	recombinase family protein	-
SFRI_RS21365	4134489..4134770	-	282	WP_024946414.1	zinc-ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4113762..4137868	24106
	-	inside	IScluster/Tn	mcr-4.3	-	4119681..4140399	20718

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-62)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11830.64 Da
• Isoelectric Point: 8.5341

>T21691 WP_011638897.1 NC_008345:c4132483-4132172 [Shewanella frigidimarina NCIMB 400]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Nucleotide

• Length: 312 bp

>T21691 NC_008345:c4132483-4132172 [Shewanella frigidimarina NCIMB 400]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACATATTTATCAGGACTTAGACAAACGATTCAGCTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCGTGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9330.74 Da
• Isoelectric Point: 6.4546

>AT21691 WP_011638898.1 NC_008345:c4132743-4132483 [Shewanella frigidimarina NCIMB 400]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Nucleotide

• Length: 261 bp

>AT21691 NC_008345:c4132743-4132483 [Shewanella frigidimarina NCIMB 400]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCGTACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATGACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Structures

Toxin

• AlphaFold DB: A0A883CRN5

Antitoxin

• AlphaFold DB: A0A2K8ZVH1