216907

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 240472..241139 Replicon chromosome
Accession NZ_CP083630
Organism Leclercia adecarboxylata strain FDAARGOS_1505

Toxin (Protein)


Gene name ypjF Uniprot ID A0A6S5KU07
Locus tag LA332_RS01075 Protein ID WP_032613324.1
Coordinates 240472..240801 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A6S5KD22
Locus tag LA332_RS01080 Protein ID WP_032613322.1
Coordinates 240822..241139 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA332_RS01045 (LA332_01045) 235532..236407 + 876 WP_032613333.1 N-acetylmannosamine kinase -
LA332_RS01050 (LA332_01050) 236404..236868 + 465 WP_032613331.1 N-acetylneuraminate anomerase -
LA332_RS01055 (LA332_01055) 236912..237766 - 855 WP_032613353.1 PA4780 family RIO1-like protein kinase -
LA332_RS01060 (LA332_01060) 237837..238739 - 903 WP_032613329.1 LysR family transcriptional regulator -
LA332_RS01065 (LA332_01065) 238848..239849 + 1002 WP_032613327.1 zinc-binding alcohol dehydrogenase family protein -
LA332_RS01070 (LA332_01070) 239866..240156 + 291 WP_167540286.1 putative quinol monooxygenase -
LA332_RS01075 (LA332_01075) 240472..240801 - 330 WP_032613324.1 TA system toxin CbtA family protein Toxin
LA332_RS01080 (LA332_01080) 240822..241139 - 318 WP_032613322.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LA332_RS01085 (LA332_01085) 241158..241379 - 222 WP_032613320.1 DUF987 domain-containing protein -
LA332_RS01090 (LA332_01090) 241388..241864 - 477 WP_032613318.1 RadC family protein -
LA332_RS01095 (LA332_01095) 241880..242338 - 459 WP_032613316.1 antirestriction protein -
LA332_RS01100 (LA332_01100) 242434..242673 - 240 WP_032613314.1 DUF905 domain-containing protein -
LA332_RS01105 (LA332_01105) 242751..243161 - 411 WP_032613312.1 hypothetical protein -
LA332_RS01110 (LA332_01110) 243251..243865 - 615 WP_032613310.1 hypothetical protein -
LA332_RS01115 (LA332_01115) 243862..244566 - 705 WP_032613308.1 WYL domain-containing protein -
LA332_RS01120 (LA332_01120) 244768..245601 - 834 WP_032613306.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12351.36 Da        Isoelectric Point: 9.5982

>T216907 WP_032613324.1 NZ_CP083630:c240801-240472 [Leclercia adecarboxylata]
MKPQPATTSRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFSDETVIQEHIDAAITLADAVNFLVEKYELVRIDRRGF
SWLQQTPYISVVDILRARRSTGLLKANVK

Download         Length: 330 bp

>T216907 NZ_CP113504:c4715818-4714931 [Pectobacterium brasiliense]
ATGCTGAAGCAACAAATTCGCCAAATCGTCCAGTCAAACCCTGACTATGCCGCAGTGACACCCGTCATAGAAAAAGAGAT
CTTGCATCATGACATTATAGATGTGCTGATCAAACAGGGTGTCATGCAACGGTTAACGTTTATTGGCGGCACCTCATTAC
GAATGTGTTACAACAGTAGCAGGCTATCAGAAGATCTTGATTTCAATGGTGGTCATGATTTCAAGCCCTCAGCATTTGAG
GGGCTGGAATCCGAGATCCAAACCTATATTCAGAACAAGTATGAAACCGAAGTTTGGGTAAACAAACCTTCTGGCGAGCG
GCAAGGGGATACCGTTTCTTGGAAAATTAGTATCGTAAAAGAAGCGAATCGTCCTGATTTGCCACGGCAAAAAATGCATA
TTGATGTCTGTGCTATTCCATCATTTGATATTGAAAAGCGCCCGCTAATCAATCATTACGACATTGTTGTACCGACTGAA
GGGATCTTGGTTCCGGTACAATCGTTACAAGAAACACTAGCCGATAAGCTGATCGCGTTAGCGTATCGGGCAAGACGTAT
AAAGCCTCGTGATATCTGGGATATTGTTTGGATTAAGCAGCGCGGCATTGATCTATCCAAAACACTGGTTGAAAAGAAAC
TCACCGCCAGACACAAGCAAACAGATGACTTTCGACAGGCGCTATCTATTCAGTTAGCTAAGTTAATGTCGGAAGATGAA
GTCCGTGACGACTTTAATATGGAAATGAGCCGCTTTATCCCTAAGCAAATTAAAGAGAGAGCCCTCGATAATCCCGAATA
TTGGGATTATGTTCAGAGAGAGGTACATGCCATCACGTCTGAGTTATTGAATGACGTAACACCAAAAAATCCATTTGATA
TGGGTTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11903.56 Da        Isoelectric Point: 6.6242

>AT216907 WP_032613322.1 NZ_CP083630:c241139-240822 [Leclercia adecarboxylata]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECQKLDVAFPHFISQMESMLITGELNPRHAHCVILYH
NDFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT216907 NZ_CP113504:c4716371-4715847 [Pectobacterium brasiliense]
ATGACTAAATCTGATGAGCTACTAAACGTATTTTCCAAAGCGGTGAACGCTGGCGGTGGCATTCACAGTGCAACAGAGCT
GGCTTTTATGCAGGGTGTGCCATGTGACTCAGCCTTTAGAAAGTTCCTAGCCGATTGCGTAAAGAAGGGATTGCTAAGAC
GAGTGGTGAAAGGCTTCTATGAAAGTGTTATTACACCACCTGAGCCTGAGACTGCCATTTATAAAATCATCAAAAAGTTG
CGCAGTGGCGTATTGAACTACATCAGTTTAGAAAGCCAGCTCAGTCATACCGGTGATATTTCACAAGTTGTGATGGGTAG
AGTCACGGTAGTGACTAAAGGTCGAAGTGGTTGTTTTGAAACGCCTTATGGCGTGATCGAGTTTACCCATACTAAAAAGC
CAGTCGAGCAAGTTGCACCTAATTTGTACTATGACCCTGACATTAAAATGTATCGCGCATACAAGGAACAAGCGATTGCA
GATCTAAAGCACTGCCAGCGCAATCTACATATGTTGGAGAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6S5KU07

Antitoxin

Source ID Structure
AlphaFold DB A0A6S5KD22

References