Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2069088..2069586 Replicon chromosome
Accession NZ_CP083627
Organism Streptococcus pneumoniae strain FDAARGOS_1508

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag LA346_RS10585 Protein ID WP_001809704.1
Coordinates 2069088..2069342 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag LA346_RS10590 Protein ID WP_000208080.1
Coordinates 2069344..2069586 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA346_RS10570 (LA346_10570) 2064361..2066829 - 2469 WP_001152990.1 DNA gyrase subunit A -
LA346_RS10575 (LA346_10575) 2067023..2068009 + 987 WP_000204727.1 L-lactate dehydrogenase -
LA346_RS10580 (LA346_10580) 2068346..2069041 - 696 WP_000731137.1 potassium channel family protein -
LA346_RS10585 (LA346_10585) 2069088..2069342 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LA346_RS10590 (LA346_10590) 2069344..2069586 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
LA346_RS10595 (LA346_10595) 2069780..2071036 + 1257 WP_000530078.1 ISL3 family transposase -
LA346_RS10600 (LA346_10600) 2071100..2071909 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
LA346_RS10605 (LA346_10605) 2071911..2073260 - 1350 WP_000886213.1 cell wall metabolism sensor histidine kinase VicK -
LA346_RS10610 (LA346_10610) 2073253..2073957 - 705 WP_000722076.1 response regulator YycF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2069780..2071036 1256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T216906 WP_001809704.1 NZ_CP083627:c2069342-2069088 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T216906 NZ_CP113504:c3996777-3996361 [Pectobacterium brasiliense]
GTGAGTCGCTTGTTCATGCTGGATACCAATATCTGTTCCTTCATTATGCGGGAACACCCTGCGGAGGTGATTGAAAAGTT
GCAGCAATGCACGCTGCGGCGTGATCGTATTGTGGTCTCTGCCATCACTTACGCTGAAATGCGTTTCGGGGCGGTTGGTA
AAAAAGCCTCGCCACGCCATATGCAACTGGTCGATGCTTTTTGCCGTCGGCTCGATGCGGTATTACCTTGGGATAGCGCC
GCAGTAGATGCCACCACGAAAATCAAAATCGAGCTAGCCGCCGCTGGCACACCTATTGGTCCAAACGATACGGCCATCGC
GGGCCATGCCATCAGCGCTAAGGCCATATTAGTTACCAATAATCTAAGAGAATTTGAGCGAGTACCGGGGCTGACGTTGG
AAGATTGGGTTAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT216906 WP_000208080.1 NZ_CP083627:c2069586-2069344 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT216906 NZ_CP113504:c3997001-3996774 [Pectobacterium brasiliense]
ATGCGTATTGTTTCGGTATTTAAAAACGGTAACAACCGTGCCATTCGCTTGCCGCGTGATATGGACTTTGAAGGGGTCAA
CGAACTGGAGATTGTGCGTGAGGGAGATACCATCATGCTGCGTCCTGTTAAACCCAATTGGCATTCGTTTTTGCAAGAAG
ATCGCGCTGACGCTGACTTTATGACAGAACGTCAGGATGTGGTCGAGGAGGGGAGATTCAAACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References