Detailed information of TA system TA216905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): zeta-pezA/zeta-couple_hipB
• Location: 1881278..1882512
• Replicon: chromosome
• Accession: NZ_CP083627
• Organism: Streptococcus pneumoniae strain FDAARGOS_1508

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: A0A0T8STN7
• Locus tag: LA346_RS09785
• Protein ID: WP_000405351.1
• Coordinates: 1881754..1882512 (+)
• Length: 253 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A0T7YHJ0
• Locus tag: LA346_RS09780
• Protein ID: WP_000579620.1
• Coordinates: 1881278..1881754 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA346_RS09760 (LA346_09760)	1876351..1877205	+	855	WP_000901913.1	ADP-ribosylglycohydrolase family protein	-
LA346_RS09765 (LA346_09765)	1877317..1878201	+	885	WP_000757475.1	diacylglycerol kinase family lipid kinase	-
LA346_RS09770 (LA346_09770)	1878364..1880103	+	1740	Protein_1897	glycoside hydrolase family 13 protein	-
LA346_RS09775 (LA346_09775)	1880378..1880833	+	456	WP_000500478.1	hypothetical protein	-
LA346_RS09780 (LA346_09780)	1881278..1881754	+	477	WP_000579620.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
LA346_RS09785 (LA346_09785)	1881754..1882512	+	759	WP_000405351.1	type II toxin-antitoxin system toxin PezT	Toxin
LA346_RS09790 (LA346_09790)	1882910..1883806	-	897	WP_000384879.1	tyrosine-type recombinase/integrase	-
LA346_RS09795 (LA346_09795)	1884136..1885905	+	1770	WP_000002882.1	DUF4365 domain-containing protein	-
LA346_RS09800 (LA346_09800)	1885934..1886218	+	285	WP_000403447.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1872489..1921774	49285

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 253 a.a.
• Molecular weight: 28752.57 Da
• Isoelectric Point: 6.5919

>T216905 WP_000405351.1 NZ_CP083627:1881754-1882512 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTTSAATVLHDLLFGELNQVEKEML
KSGEERLKDLTN

Nucleotide

• Length: 759 bp

>T216905 NZ_CP113504:1807973-1808377 [Pectobacterium brasiliense]
ATGCTGAAATATCTGCTCGATACCAATATCTGTATTTACACCATCAAGAACAAACCGCAGGAAGTCAGGGACGCTTTCTA
CCGCCATTACGGGCAGTTTGCTATCAGTGCTATCACGCTGATGGAGCTGATTTACGGCGCGGAGAAATCGGTAAACCCAG
AAAAGAATCTCGCCGTGATTGAAGGGTTTTCTGCGCGTCTGGAAGTGCAAACTTATGGCTTTGACGCTGCCGTACATACG
GGGCAAATTCGTGCGGAACTGGCAAGACAAGGAACCCCCATCGGCCCGTATGATGCCATGTTAGCGGGTCATGCGCGGTC
CGCAGGTTTGATTCTGGTAACGAACAATGTGCGTGAGTTTGAGCGTGTGCCAGGATTGCGCGTAGAAAACTGGGTCGGTA
GATAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18235.65 Da
• Isoelectric Point: 4.3462

>AT216905 WP_000579620.1 NZ_CP083627:1881278-1881754 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT216905 NZ_CP113504:1807743-1807973 [Pectobacterium brasiliense]
ATGGAAAAAACCACAGTATTTAAAAGCAATCGCAGCCAGGCGGTACGGCTCCCTAAAGCCGTTGCGCTGCCCGATGATGT
GAAGCAGGTTGATATCGTTGCGATTGGTCGCACACGTATCATTACTCCGGCAGGCGAAAGCTGGGACAGTTGGTTCGAAG
AAGATGGAGTAACACCTGACTTTATGATCACCAGAGAGCAACCCGATGATCAGATCAGGGAAGATTTCTGA

Structures

Toxin

• AlphaFold DB: A0A0T8STN7

Antitoxin

• AlphaFold DB: A0A0T7YHJ0