Detailed information of TA system TA216904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 452333..453001
• Replicon: chromosome
• Accession: NZ_CP083627
• Organism: Streptococcus pneumoniae strain FDAARGOS_1508

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LA346_RS02415
• Protein ID: WP_001132283.1
• Coordinates: 452822..453001 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: LA346_RS02410
• Protein ID: WP_000961810.1
• Coordinates: 452333..452785 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA346_RS02385 (LA346_02385)	448223..448966	-	744	WP_001188208.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
LA346_RS02390 (LA346_02390)	448968..449918	-	951	WP_000451131.1	50S ribosomal protein L11 methyltransferase	-
LA346_RS02395 (LA346_02395)	450056..450484	-	429	WP_000418156.1	NUDIX hydrolase	-
LA346_RS02400 (LA346_02400)	450465..451553	-	1089	WP_000719724.1	site-2 protease family protein	-
LA346_RS02405 (LA346_02405)	451572..452042	-	471	WP_000257097.1	DUF3013 family protein	-
LA346_RS02410 (LA346_02410)	452333..452785	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LA346_RS02415 (LA346_02415)	452822..453001	-	180	WP_001132283.1	type II toxin-antitoxin system HicA family toxin	Toxin
LA346_RS02420 (LA346_02420)	453138..453317	-	180	WP_001809903.1	hypothetical protein	-
LA346_RS02425 (LA346_02425)	453482..453721	-	240	WP_000818079.1	hypothetical protein	-
LA346_RS02430 (LA346_02430)	453991..455262	+	1272	WP_001113216.1	replication-associated recombination protein A	-
LA346_RS02440 (LA346_02440)	455806..457125	-	1320	WP_000502554.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6596.78 Da
• Isoelectric Point: 10.8214

>T216904 WP_001132283.1 NZ_CP083627:c453001-452822 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 180 bp

>T216904 NZ_CP113504:c1498885-1498466 [Pectobacterium brasiliense]
ATGACAGATATCTTGCTCAACAAAAGCAGCACCATACAAAGATGCCTACGTCGTATCCGTGAGGAATTCGATACTGAGGA
AGGGTTTCGTCAGAACTTCACCAAGCAAGATTCCGTCATACTCAACATACAGCGCGCCTGCGAAGCCGCGATTGATATCG
CCAATTATCTTATCCGTATCAAGCAGCTAGGTATACCACAGAGTAGCCGCGATAGCTTTGCGCTTCTCGCTGCAAACCAG
ATTATTACTCTTGAACTCTCTGACAATTTGCAAAAAATGGTGGGATTAAGAAATATTGCCGTGCATGACTATCAGGCGCT
AAATTTGGATATTGTCATCCACGTCATTTCTCATCGTTTAAGCGACTTCGAACGTTTTATCAAAGAAATAGCCCGATATA
GCGACAGCCAGCACCTCTAG

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT216904 WP_000961810.1 NZ_CP083627:c452785-452333 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT216904 NZ_CP113504:c1499265-1498882 [Pectobacterium brasiliense]
ATGTTCGATGAGATCGTTTTGACACTGAAAAAACAGATGCCCGACATCAAGATTATTTACCTCTTTGGTTCCCAGGCAAC
GGGCAATGCCAGAGCAGATAGCGATGTTGATATCGCAATCATGGCGACGAGAGCCCTGGATCCCGTTGAACGCTGGGAGC
TATCCCACCAGCTAGCAAAAACAGTAGGCCATGATGTCGATCTTATCGATTTATTGCAGGCCTCGACGGTATTAAAAATG
GAGGTCGTTCGTAACGGCAAGCTACTTTACGATGCGGAAGCAACGGCAGGAGAATTTGAAATGACAACACTTTCGATGTA
CCAGCATCTGCAAAAAGAGCGTGCGGATATCATTCGTAGCTTTAATCAGGATCTAAAAGCATGA

Structures

Antitoxin

• PDB: 5YRZ
• AlphaFold DB: G0IC64