Detailed information of TA system TA021690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1430534..1431207
• Replicon: chromosome
• Accession: NC_008344
• Organism: Nitrosomonas eutropha C91

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q0AGC5
• Locus tag: NEUT_RS06885
• Protein ID: WP_011634415.1
• Coordinates: 1430534..1430962 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: NEUT_RS06890
• Protein ID: WP_041353760.1
• Coordinates: 1430962..1431207 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NEUT_RS06875	1427146..1429188	+	2043	WP_011634413.1	exodeoxyribonuclease V subunit alpha	-
NEUT_RS06880	1429207..1430511	-	1305	WP_011634414.1	M18 family aminopeptidase	-
NEUT_RS06885	1430534..1430962	-	429	WP_011634415.1	PIN domain-containing protein	Toxin
NEUT_RS06890	1430962..1431207	-	246	WP_041353760.1	hypothetical protein	Antitoxin
NEUT_RS06895	1431292..1432629	-	1338	WP_011634417.1	GHKL domain-containing protein	-
NEUT_RS06900	1432626..1433312	-	687	WP_011634418.1	response regulator transcription factor	-
NEUT_RS06905	1433381..1433671	-	291	WP_011634419.1	PepSY domain-containing protein	-
NEUT_RS06910	1433757..1434116	-	360	WP_041353492.1	DUF3824 domain-containing protein	-
NEUT_RS06915	1434414..1434959	+	546	WP_041353761.1	DUF924 domain-containing protein	-
NEUT_RS06920	1435095..1436075	-	981	WP_207204494.1	integron integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-126)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15818.16 Da
• Isoelectric Point: 6.4862

>T21690 WP_011634415.1 NC_008344:c1430962-1430534 [Nitrosomonas eutropha C91]
MRALLDVNVLIALLDAGHVHHVRASQWLEQEIIHGWASCPLTQNGCLRIMTQPAYPEALSLAAVASRLAQAIAHPTHAFV
ADDYSLLDAEQVNWQQMLGHWQIIDSYLLGLAVRHHCRFVSFDSRLNPDIVSGASQQHIVIL

Nucleotide

• Length: 429 bp

>T21690 NC_008344:c1430962-1430534 [Nitrosomonas eutropha C91]
ATGCGCGCTTTGCTTGACGTCAACGTGTTGATTGCCCTGCTTGATGCGGGCCATGTCCATCATGTTCGTGCCAGTCAATG
GCTGGAGCAGGAGATCATCCACGGTTGGGCTTCTTGTCCGCTCACCCAAAACGGGTGTCTGCGCATCATGACTCAGCCGG
CCTATCCGGAAGCATTGTCACTGGCTGCTGTGGCCAGCCGATTAGCACAGGCTATAGCGCATCCAACCCATGCATTTGTA
GCAGATGATTACAGTCTGCTGGATGCAGAACAAGTAAACTGGCAACAAATGCTTGGTCATTGGCAAATTATTGACAGTTA
TTTGCTGGGGCTCGCTGTACGCCATCATTGCCGTTTTGTCAGCTTCGATTCGCGCCTGAACCCGGACATTGTTTCAGGTG
CAAGCCAACAACATATTGTAATTTTATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8713.81 Da
• Isoelectric Point: 5.0644

>AT21690 WP_041353760.1 NC_008344:c1431207-1430962 [Nitrosomonas eutropha C91]
VRTTIDIENDVLAAAKEIARTENVSVGKVISRLVRQALAGHVAEVSSPDDASSVTGFRPFPSRGVIVSNELINRLRDEEG
I

Nucleotide

• Length: 246 bp

>AT21690 NC_008344:c1431207-1430962 [Nitrosomonas eutropha C91]
GTGCGTACCACGATAGATATTGAGAACGATGTTCTTGCCGCCGCAAAGGAAATTGCCCGTACGGAAAATGTAAGCGTTGG
CAAAGTTATATCACGTCTTGTGCGCCAGGCTCTGGCTGGCCATGTTGCCGAAGTATCTTCTCCTGACGATGCCTCTTCTG
TAACCGGTTTTCGGCCATTTCCATCGCGTGGCGTAATTGTCAGCAACGAACTTATTAATCGCCTGCGTGATGAAGAAGGT
ATTTGA

Structures

Toxin

• AlphaFold DB: Q0AGC5