Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 845644..846301 Replicon chromosome
Accession NZ_CP083620
Organism Enterobacter bugandensis strain FDAARGOS_1520

Toxin (Protein)


Gene name cptA Uniprot ID A0A2J7SFN6
Locus tag LA316_RS04090 Protein ID WP_028014322.1
Coordinates 845891..846301 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag LA316_RS04085 Protein ID WP_010435322.1
Coordinates 845644..845910 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA316_RS04065 (LA316_04065) 841075..842508 - 1434 WP_059358111.1 6-phospho-beta-glucosidase BglA -
LA316_RS04070 (LA316_04070) 842625..843356 - 732 WP_028014325.1 MurR/RpiR family transcriptional regulator -
LA316_RS04075 (LA316_04075) 843622..844281 + 660 WP_023331242.1 hemolysin III family protein -
LA316_RS04080 (LA316_04080) 844369..845349 - 981 WP_048960833.1 tRNA-modifying protein YgfZ -
LA316_RS04085 (LA316_04085) 845644..845910 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
LA316_RS04090 (LA316_04090) 845891..846301 + 411 WP_028014322.1 protein YgfX Toxin
LA316_RS04095 (LA316_04095) 846308..846829 - 522 WP_041908355.1 flavodoxin FldB -
LA316_RS04100 (LA316_04100) 846931..847827 + 897 WP_028014320.1 site-specific tyrosine recombinase XerD -
LA316_RS04105 (LA316_04105) 847856..848569 + 714 WP_049136419.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LA316_RS04110 (LA316_04110) 848575..850308 + 1734 WP_041908356.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16024.98 Da        Isoelectric Point: 11.2845

>T216889 WP_028014322.1 NZ_CP083620:845891-846301 [Enterobacter bugandensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGVPWMLNAGMMLRLRKVGGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T216889 NZ_CP113503:c4652554-4652381 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT216889 WP_010435322.1 NZ_CP083620:845644-845910 [Enterobacter bugandensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216889 NZ_CP113503:c4652878-4652582 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7SFN6

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References