Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4083208..4083865 Replicon chromosome
Accession NZ_CP083613
Organism Enterobacter hormaechei subsp. oharae strain FDAARGOS_1533

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag LA353_RS19645 Protein ID WP_017382887.1
Coordinates 4083208..4083618 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LA353_RS19650 Protein ID WP_003863437.1
Coordinates 4083599..4083865 (-) Length 89 a.a.

Genomic Context

LA353_RS19640LA353_RS19655LA353_RS19665LA353_RS19670LA353_RS19625LA353_RS19630LA353_RS19635LA353_RS19645LA353_RS19650LA353_RS19660
Location: 4082685..4083206 (522 bp)
Type: Others
Protein ID: WP_015571793.1
Location: 4084160..4085140 (981 bp)
Type: Others
Protein ID: WP_022649306.1
Location: 4086178..4086909 (732 bp)
Type: Others
Protein ID: WP_047050802.1
Location: 4087026..4088459 (1434 bp)
Type: Others
Protein ID: WP_023295383.1
Location: 4079206..4080939 (1734 bp)
Type: Others
Protein ID: WP_047050807.1
Location: 4080945..4081658 (714 bp)
Type: Others
Protein ID: WP_003863443.1
Location: 4081687..4082583 (897 bp)
Type: Others
Protein ID: WP_047050805.1
Location: 4083208..4083618 (411 bp)
Type: Toxin
Protein ID: WP_017382887.1
Location: 4083599..4083865 (267 bp)
Type: Antitoxin
Protein ID: WP_003863437.1
Location: 4085252..4085911 (660 bp)
Type: Others
Protein ID: WP_047050804.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LA353_RS19625 (LA353_19620)4079206..4080939-1734WP_047050807.1single-stranded-DNA-specific exonuclease RecJ-
LA353_RS19630 (LA353_19625)4080945..4081658-714WP_003863443.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
LA353_RS19635 (LA353_19630)4081687..4082583-897WP_047050805.1site-specific tyrosine recombinase XerD-
LA353_RS19640 (LA353_19635)4082685..4083206+522WP_015571793.1flavodoxin FldB-
LA353_RS19645 (LA353_19640)4083208..4083618-411WP_017382887.1protein YgfXToxin
LA353_RS19650 (LA353_19645)4083599..4083865-267WP_003863437.1FAD assembly factor SdhEAntitoxin
LA353_RS19655 (LA353_19650)4084160..4085140+981WP_022649306.1tRNA-modifying protein YgfZ-
LA353_RS19660 (LA353_19655)4085252..4085911-660WP_047050804.1hemolysin III family protein-
LA353_RS19665 (LA353_19660)4086178..4086909+732WP_047050802.1MurR/RpiR family transcriptional regulator-
LA353_RS19670 (LA353_19665)4087026..4088459+1434WP_023295383.16-phospho-beta-glucosidase BglA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T216877 WP_017382887.1 NZ_CP083613:c4083618-4083208 [Enterobacter hormaechei subsp. oharae]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T216877 NZ_CP113503:2556130-2557452 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGATAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTAATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT216877 WP_003863437.1 NZ_CP083613:c4083865-4083599 [Enterobacter hormaechei subsp. oharae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT216877 NZ_CP113503:2555864-2556130 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAATTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
GCAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A179PSF7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A837F8P5

References