Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2639611..2640350 Replicon chromosome
Accession NZ_CP083613
Organism Enterobacter hormaechei subsp. oharae strain FDAARGOS_1533

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag LA353_RS12795 Protein ID WP_045329830.1
Coordinates 2639611..2640096 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag LA353_RS12800 Protein ID WP_047050951.1
Coordinates 2640084..2640350 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA353_RS12775 (LA353_12770) 2635764..2636522 - 759 WP_047050948.1 trans-aconitate 2-methyltransferase -
LA353_RS12780 (LA353_12775) 2636607..2637191 - 585 WP_047050949.1 NUDIX domain-containing protein -
LA353_RS12785 (LA353_12780) 2637278..2638036 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
LA353_RS12790 (LA353_12785) 2638141..2639433 + 1293 WP_047050950.1 glycosyl hydrolase family 28 protein -
LA353_RS12795 (LA353_12790) 2639611..2640096 - 486 WP_045329830.1 GNAT family N-acetyltransferase Toxin
LA353_RS12800 (LA353_12795) 2640084..2640350 - 267 WP_047050951.1 DUF1778 domain-containing protein Antitoxin
LA353_RS12805 (LA353_12800) 2640414..2641343 - 930 WP_047050986.1 LysR family transcriptional regulator -
LA353_RS12810 (LA353_12805) 2641473..2642861 + 1389 WP_047050952.1 MFS transporter -
LA353_RS12815 (LA353_12810) 2642883..2643878 - 996 WP_047050954.1 DUF2891 domain-containing protein -
LA353_RS12820 (LA353_12815) 2643888..2644874 - 987 WP_047050955.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17512.18 Da        Isoelectric Point: 9.9658

>T216866 WP_045329830.1 NZ_CP083613:c2640096-2639611 [Enterobacter hormaechei subsp. oharae]
VGRVTAPEPLSSAHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T216866 NZ_CP113500:c787980-787684 [Mycoplasma feriruminatoris]
ATGACTAAATATAAAATTGTTTGAACAACAAAATTTAAAAAGGATTTAAAGCTAGCTAAAAAACAGAACAAAGATTTAAA
TAAACTAGACTATGTTATTAATATATTAATTCAAGGCAAAGAGTTAGACGCAAAATATCAGGATCATTCACTTACTGGCA
TTTATAAAGAATATAGAGAGTGTCATATTGACCCTGACTGATTTTTAATATATAAAAAAGATGATGATAAAATTGTTATA
ATAATGTTAAGATTAGGTTCACATTCTAATTTATTTGAAAAACAAAAAAACTACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10089.51 Da        Isoelectric Point: 4.4857

>AT216866 WP_047050951.1 NZ_CP083613:c2640350-2640084 [Enterobacter hormaechei subsp. oharae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVANDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT216866 NZ_CP113500:c788245-787973 [Mycoplasma feriruminatoris]
ATGAAAACAACAAATTTAAACGTAAGAATTGATAAAGAAGTCAAACATGATGCAGAAGCTATATTTAATGAATTGGGTTT
AAGCACATCAGCAGCTATAAATATGTTTTTTAAGGCTACAATTAGAAATAACAGTCTTCCTTTTAGCACTAAACTGGATA
CTCCTAATAAAGAAACTTTGTTAGCTATGAAAGAAGCAGAAGAACTATTAAAAGATCCAAATACAAAGTATTATTCAAGC
TTTAAAGAACTTTTAGAGACATTAGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References