Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1399833..1400453 Replicon chromosome
Accession NZ_CP083613
Organism Enterobacter hormaechei subsp. oharae strain FDAARGOS_1533

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LA353_RS06570 Protein ID WP_015571250.1
Coordinates 1399833..1400051 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LA353_RS06575 Protein ID WP_006809850.1
Coordinates 1400079..1400453 (-) Length 125 a.a.

Genomic Context

LA353_RS06540LA353_RS06545LA353_RS06555LA353_RS06550LA353_RS06560LA353_RS06565LA353_RS06570LA353_RS06575LA353_RS06580LA353_RS06585
Location: 1395845..1396105 (261 bp)
Type: Others
Protein ID: WP_015571255.1
Location: 1396108..1396248 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 1397057..1398517 (1461 bp)
Type: Others
Protein ID: WP_047051117.1
Location: 1396245..1396955 (711 bp)
Type: Others
Protein ID: WP_047051118.1
Location: 1398489..1398956 (468 bp)
Type: Others
Protein ID: WP_017383209.1
Location: 1399073..1399624 (552 bp)
Type: Others
Protein ID: WP_017694396.1
Location: 1399833..1400051 (219 bp)
Type: Toxin
Protein ID: WP_015571250.1
Location: 1400079..1400453 (375 bp)
Type: Antitoxin
Protein ID: WP_006809850.1
Location: 1400963..1404109 (3147 bp)
Type: Others
Protein ID: WP_047051116.1
Location: 1404132..1405325 (1194 bp)
Type: Others
Protein ID: WP_047051115.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LA353_RS06540 (LA353_06540)1395845..1396105+261WP_015571255.1type B 50S ribosomal protein L31-
LA353_RS06545 (LA353_06545)1396108..1396248+141WP_003859006.1type B 50S ribosomal protein L36-
LA353_RS06550 (LA353_06550)1396245..1396955-711WP_047051118.1GNAT family protein-
LA353_RS06555 (LA353_06555)1397057..1398517+1461WP_047051117.1PLP-dependent aminotransferase family protein-
LA353_RS06560 (LA353_06560)1398489..1398956-468WP_017383209.1YlaC family protein-
LA353_RS06565 (LA353_06565)1399073..1399624-552WP_017694396.1maltose O-acetyltransferase-
LA353_RS06570 (LA353_06570)1399833..1400051-219WP_015571250.1HHA domain-containing proteinToxin
LA353_RS06575 (LA353_06575)1400079..1400453-375WP_006809850.1Hha toxicity modulator TomBAntitoxin
LA353_RS06580 (LA353_06580)1400963..1404109-3147WP_047051116.1multidrug efflux RND transporter permease subunit AcrB-
LA353_RS06585 (LA353_06585)1404132..1405325-1194WP_047051115.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T216863 WP_015571250.1 NZ_CP083613:c1400051-1399833 [Enterobacter hormaechei subsp. oharae]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T216863 NZ_CP113497:c793108-792812 [Mycoplasma feriruminatoris]
ATGACTAAATATAAAATTGTTTGAACAACAAAATTTAAAAAGGATTTAAAGCTAGCTAAAAAACAGAATAAAGATTTAAA
TAAACTAGACTATGTTATTAATATATTAACTCAAGGCAAAGAGTTAGACGCAAAATATCAGGATCATTCACTTACTGGCA
TTTATAAAGAATATAGAGAGTGTCATATTGACCCTGACTGACTTTTAATATATAAAAAAGATGATGATAAAATTGTTATA
ATAATGTTAAGATTAGGTTCACATTCTAATTTATTTGAAAAACAAAAAAACTACTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT216863 WP_006809850.1 NZ_CP083613:c1400453-1400079 [Enterobacter hormaechei subsp. oharae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT216863 NZ_CP113497:c793373-793101 [Mycoplasma feriruminatoris]
ATGAAAACAACAAATTTAAACGTAAGAATTGATAAAGAAGTCAAACATGATGCAGAAGCTATATTTAATGAATTGGGTTT
AAGCACATCAGCAGCTATAAATATGTTTTTTAAGGCTACAATTAGAAATAACAGTCTTCCTTTTAGCACTAAACTGGATA
CTCCTAATAAAGAAACTTTGTTAGCTATGAAAGAAGCAGAAGAACTATTAAAAGATCCAAATACAAAGTATTATTCAAGC
TTTAAAGAACTTTTAGAGACATTAGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A837FFM2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A837FGN8

References