Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1399833..1400453 Replicon chromosome
Accession NZ_CP083613
Organism Enterobacter hormaechei subsp. oharae strain FDAARGOS_1533

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LA353_RS06570 Protein ID WP_015571250.1
Coordinates 1399833..1400051 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LA353_RS06575 Protein ID WP_006809850.1
Coordinates 1400079..1400453 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA353_RS06540 (LA353_06540) 1395845..1396105 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LA353_RS06545 (LA353_06545) 1396108..1396248 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LA353_RS06550 (LA353_06550) 1396245..1396955 - 711 WP_047051118.1 GNAT family protein -
LA353_RS06555 (LA353_06555) 1397057..1398517 + 1461 WP_047051117.1 PLP-dependent aminotransferase family protein -
LA353_RS06560 (LA353_06560) 1398489..1398956 - 468 WP_017383209.1 YlaC family protein -
LA353_RS06565 (LA353_06565) 1399073..1399624 - 552 WP_017694396.1 maltose O-acetyltransferase -
LA353_RS06570 (LA353_06570) 1399833..1400051 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LA353_RS06575 (LA353_06575) 1400079..1400453 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LA353_RS06580 (LA353_06580) 1400963..1404109 - 3147 WP_047051116.1 multidrug efflux RND transporter permease subunit AcrB -
LA353_RS06585 (LA353_06585) 1404132..1405325 - 1194 WP_047051115.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T216863 WP_015571250.1 NZ_CP083613:c1400051-1399833 [Enterobacter hormaechei subsp. oharae]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T216863 NZ_CP113497:c793108-792812 [Mycoplasma feriruminatoris]
ATGACTAAATATAAAATTGTTTGAACAACAAAATTTAAAAAGGATTTAAAGCTAGCTAAAAAACAGAATAAAGATTTAAA
TAAACTAGACTATGTTATTAATATATTAACTCAAGGCAAAGAGTTAGACGCAAAATATCAGGATCATTCACTTACTGGCA
TTTATAAAGAATATAGAGAGTGTCATATTGACCCTGACTGACTTTTAATATATAAAAAAGATGATGATAAAATTGTTATA
ATAATGTTAAGATTAGGTTCACATTCTAATTTATTTGAAAAACAAAAAAACTACTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT216863 WP_006809850.1 NZ_CP083613:c1400453-1400079 [Enterobacter hormaechei subsp. oharae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT216863 NZ_CP113497:c793373-793101 [Mycoplasma feriruminatoris]
ATGAAAACAACAAATTTAAACGTAAGAATTGATAAAGAAGTCAAACATGATGCAGAAGCTATATTTAATGAATTGGGTTT
AAGCACATCAGCAGCTATAAATATGTTTTTTAAGGCTACAATTAGAAATAACAGTCTTCCTTTTAGCACTAAACTGGATA
CTCCTAATAAAGAAACTTTGTTAGCTATGAAAGAAGCAGAAGAACTATTAAAAGATCCAAATACAAAGTATTATTCAAGC
TTTAAAGAACTTTTAGAGACATTAGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References