Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 1267300..1268009 | Replicon | chromosome |
| Accession | NZ_CP083613 | ||
| Organism | Enterobacter hormaechei subsp. oharae strain FDAARGOS_1533 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A7D6YAQ1 |
| Locus tag | LA353_RS05945 | Protein ID | WP_071886833.1 |
| Coordinates | 1267641..1268009 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | LA353_RS05940 | Protein ID | WP_047051179.1 |
| Coordinates | 1267300..1267620 (+) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LA353_RS05895 (LA353_05895) | 1262534..1262764 | + | 231 | Protein_1126 | hypothetical protein | - |
| LA353_RS05900 (LA353_05900) | 1262860..1263694 | + | 835 | Protein_1127 | DUF932 domain-containing protein | - |
| LA353_RS05905 (LA353_05905) | 1263896..1264600 | + | 705 | WP_047051185.1 | WYL domain-containing protein | - |
| LA353_RS05910 (LA353_05910) | 1264597..1265211 | + | 615 | WP_047051184.1 | hypothetical protein | - |
| LA353_RS05915 (LA353_05915) | 1265300..1265710 | + | 411 | WP_047051183.1 | hypothetical protein | - |
| LA353_RS05920 (LA353_05920) | 1265787..1266023 | + | 237 | WP_047051182.1 | DUF905 domain-containing protein | - |
| LA353_RS05925 (LA353_05925) | 1266103..1266561 | + | 459 | WP_047051181.1 | antirestriction protein | - |
| LA353_RS05930 (LA353_05930) | 1266570..1267052 | + | 483 | WP_075211782.1 | DNA repair protein RadC | - |
| LA353_RS05935 (LA353_05935) | 1267061..1267282 | + | 222 | WP_016243789.1 | DUF987 domain-containing protein | - |
| LA353_RS05940 (LA353_05940) | 1267300..1267620 | + | 321 | WP_047051179.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LA353_RS05945 (LA353_05945) | 1267641..1268009 | + | 369 | WP_071886833.1 | TA system toxin CbtA family protein | Toxin |
| LA353_RS05950 (LA353_05950) | 1268355..1269101 | - | 747 | WP_047051178.1 | class I SAM-dependent methyltransferase | - |
| LA353_RS05955 (LA353_05955) | 1269112..1269369 | - | 258 | WP_003863178.1 | YjhX family toxin | - |
| LA353_RS05960 (LA353_05960) | 1269629..1271566 | - | 1938 | WP_047051177.1 | bifunctional diguanylate cyclase/phosphodiesterase | - |
| LA353_RS05965 (LA353_05965) | 1271584..1272078 | - | 495 | WP_047051176.1 | molybdopterin-dependent oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1256598..1268009 | 11411 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13738.90 Da Isoelectric Point: 8.1347
>T216862 WP_071886833.1 NZ_CP083613:1267641-1268009 [Enterobacter hormaechei subsp. oharae]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ
Download Length: 369 bp
>T216862 NZ_CP113496:c791996-791655 [Mycoplasma feriruminatoris]
ATGACTAAATATAAAATTGTTTGAACAACAAAATTTAAAAAGGATTTAAAGCTAGCTAAAAAACAGAATAAAGATTTAAA
TAAACTAGACTATGTTATTAATATATTAATTCAAGGCAAAGAGTTAGACGCAAAATATCAGGATCATTCACTTACTGGCA
TTTATAAAGAATATAGAGAGTGTCATATTGACCCTGACTGATTTTTAATATATAAAAAAGATGATGATAAAATTGTTATA
ATAATGTTAAGATTAGGTTCACATTCTAATTTATTTGAAAAACAAAAAACTACTAGGCTAAACAAAAAACAGCTTCCCCC
CGCTACCATAAACACGGACTAA
ATGACTAAATATAAAATTGTTTGAACAACAAAATTTAAAAAGGATTTAAAGCTAGCTAAAAAACAGAATAAAGATTTAAA
TAAACTAGACTATGTTATTAATATATTAATTCAAGGCAAAGAGTTAGACGCAAAATATCAGGATCATTCACTTACTGGCA
TTTATAAAGAATATAGAGAGTGTCATATTGACCCTGACTGATTTTTAATATATAAAAAAGATGATGATAAAATTGTTATA
ATAATGTTAAGATTAGGTTCACATTCTAATTTATTTGAAAAACAAAAAACTACTAGGCTAAACAAAAAACAGCTTCCCCC
CGCTACCATAAACACGGACTAA
Antitoxin
Download Length: 107 a.a. Molecular weight: 11901.60 Da Isoelectric Point: 7.2633
>AT216862 WP_047051179.1 NZ_CP083613:1267300-1267620 [Enterobacter hormaechei subsp. oharae]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS
Download Length: 321 bp
>AT216862 NZ_CP113496:c792261-791989 [Mycoplasma feriruminatoris]
ATGAAAACAACAAATCTAAACGTAAGAATTGATAAAGAAGTCAAACATGATGCAGAAGCTATATTTAATGAATTGGGTTT
AAGCACATCAGCAGCTATAAATATGTTTTTTAAGGCTACAATTAGAAATAACAGTCTTCCTTTTAGTACTAAACTGGATA
CTCCTAATAAAGAAACTTTGTTAGCTATGAAAGAAGCAGAAGAACTATTAAAAGATCCAAATACAAAGTATTATTCAAGC
TTTAAAGAACTTTTAGAGACATTAGATGACTAA
ATGAAAACAACAAATCTAAACGTAAGAATTGATAAAGAAGTCAAACATGATGCAGAAGCTATATTTAATGAATTGGGTTT
AAGCACATCAGCAGCTATAAATATGTTTTTTAAGGCTACAATTAGAAATAACAGTCTTCCTTTTAGTACTAAACTGGATA
CTCCTAATAAAGAAACTTTGTTAGCTATGAAAGAAGCAGAAGAACTATTAAAAGATCCAAATACAAAGTATTATTCAAGC
TTTAAAGAACTTTTAGAGACATTAGATGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|