Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 636018..636614 Replicon chromosome
Accession NZ_CP083613
Organism Enterobacter hormaechei subsp. oharae strain FDAARGOS_1533

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag LA353_RS02955 Protein ID WP_023315213.1
Coordinates 636312..636614 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag LA353_RS02950 Protein ID WP_022650216.1
Coordinates 636018..636305 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA353_RS02945 (LA353_02945) 634390..636021 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
LA353_RS02950 (LA353_02950) 636018..636305 - 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
LA353_RS02955 (LA353_02955) 636312..636614 - 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LA353_RS02960 (LA353_02960) 636812..637684 + 873 WP_022646725.1 23S rRNA pseudouridine(2604) synthase RluF -
LA353_RS02965 (LA353_02965) 637685..637957 - 273 WP_047052050.1 DUF3811 domain-containing protein -
LA353_RS02970 (LA353_02970) 638008..638952 - 945 WP_032627014.1 ketopantoate/pantoate/pantothenate transporter PanS -
LA353_RS02975 (LA353_02975) 639046..640395 - 1350 WP_045344657.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T216861 WP_023315213.1 NZ_CP083613:c636614-636312 [Enterobacter hormaechei subsp. oharae]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T216861 NZ_CP113495:c785190-784894 [Mycoplasma feriruminatoris]
ATGACTAAATATAAAATTGTTTGAACAACAAAATTTAAAAAGGATTTAAAGCTAGCTAAAAAACAGAATAAAGATTTAAA
TAAACTAGACTATGTTATTAATATATTAATTCAAGGCAAAGAGTTAGACGCAAAATATCAGGATCATTCACTTACTGGCA
TTTATAAAAAATATAGAGAGTGTCATATTGACCCTGACTGACTTTTAATATATAAAAAAGATGATGATAAAATTGTTATA
ATAATGTTAAGATTAGGTTCACATTCTAATTTATTTGAAAAACAAAAAAACTACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT216861 WP_022650216.1 NZ_CP083613:c636305-636018 [Enterobacter hormaechei subsp. oharae]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT216861 NZ_CP113495:c785455-785183 [Mycoplasma feriruminatoris]
ATGAAAACAACAAATTTAAACGTAAGAATTGATAAAGAAGTCAAACATGATGCAGAAGCTATATTTAATGAATTGGGTTT
AAGCACATCAGCAGCTATAAATATGTTTTTTAAGGCTACAATTAGAAATAACAGTCTTCCTTTTAGCACTAAACTGGATA
CTCCTAATAAAGAAACTTTGTTAGCTATGAAAGAAGCAGAAGAACTATTAAAAGATCCAAATACAAAGTATTATTCAAGC
TTTAAAGAACTTTTAGAGACATTAGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References