Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 407106..407762 Replicon chromosome
Accession NZ_CP083613
Organism Enterobacter hormaechei subsp. oharae strain FDAARGOS_1533

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LA353_RS01870 Protein ID WP_080344062.1
Coordinates 407106..407498 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LA353_RS01875 Protein ID WP_047050676.1
Coordinates 407502..407762 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA353_RS01845 (LA353_01845) 402766..403431 - 666 WP_072190036.1 LuxR C-terminal-related transcriptional regulator -
LA353_RS01850 (LA353_01850) 403972..404592 + 621 WP_047050680.1 LuxR C-terminal-related transcriptional regulator -
LA353_RS01855 (LA353_01855) 404668..405348 + 681 WP_047050679.1 EAL domain-containing protein -
LA353_RS01860 (LA353_01860) 405382..406182 - 801 WP_047050678.1 lipoprotein NlpA -
LA353_RS01865 (LA353_01865) 406564..407037 + 474 WP_032674176.1 hypothetical protein -
LA353_RS01870 (LA353_01870) 407106..407498 - 393 WP_080344062.1 type II toxin-antitoxin system VapC family toxin Toxin
LA353_RS01875 (LA353_01875) 407502..407762 - 261 WP_047050676.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LA353_RS01880 (LA353_01880) 407880..409364 - 1485 WP_224213919.1 MDR family MFS transporter -
LA353_RS01885 (LA353_01885) 409458..410105 + 648 WP_017383663.1 TetR/AcrR family transcriptional regulator -
LA353_RS01890 (LA353_01890) 410102..410521 - 420 WP_047050673.1 GNAT family N-acetyltransferase -
LA353_RS01895 (LA353_01895) 410707..411276 + 570 WP_032103771.1 TetR/AcrR family transcriptional regulator -
LA353_RS01900 (LA353_01900) 411424..412545 + 1122 WP_047050671.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 396655..407762 11107


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14585.78 Da        Isoelectric Point: 5.8985

>T216860 WP_080344062.1 NZ_CP083613:c407498-407106 [Enterobacter hormaechei subsp. oharae]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITVCAWDSEAAAIYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDHAFGMVQDLTVEDWTQ

Download         Length: 393 bp

>T216860 NZ_CP113494:c144328-144023 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10084.38 Da        Isoelectric Point: 9.6899

>AT216860 WP_047050676.1 NZ_CP083613:c407762-407502 [Enterobacter hormaechei subsp. oharae]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKARHRDNFLRMLKETHVPDTFLSKEERNQSYTTR
NPLEGL

Download         Length: 261 bp

>AT216860 NZ_CP113494:c144548-144330 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References