Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3850998..3851636 Replicon chromosome
Accession NZ_CP083610
Organism Escherichia coli strain EC2648-Vir1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag LAJ48_RS18610 Protein ID WP_000813794.1
Coordinates 3851460..3851636 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LAJ48_RS18605 Protein ID WP_001270286.1
Coordinates 3850998..3851414 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ48_RS18585 (3846150) 3846150..3847091 - 942 WP_001251304.1 ABC transporter permease -
LAJ48_RS18590 (3847092) 3847092..3848105 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LAJ48_RS18595 (3848123) 3848123..3849268 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
LAJ48_RS18600 (3849513) 3849513..3850919 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
LAJ48_RS18605 (3850998) 3850998..3851414 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LAJ48_RS18610 (3851460) 3851460..3851636 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LAJ48_RS18615 (3851858) 3851858..3852088 + 231 WP_000494244.1 YncJ family protein -
LAJ48_RS18620 (3852180) 3852180..3854141 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LAJ48_RS18625 (3854214) 3854214..3854750 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LAJ48_RS18630 (3854842) 3854842..3856017 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T216851 WP_000813794.1 NZ_CP083610:c3851636-3851460 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T216851 NZ_CP113493:c3277285-3277182 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT216851 WP_001270286.1 NZ_CP083610:c3851414-3850998 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT216851 NZ_CP113493:3277144-3277415 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References