Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4053198..4054739 Replicon chromosome
Accession NC_008321
Organism Shewanella sp. MR-4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag SHEWMR4_RS17735 Protein ID WP_011624127.1
Coordinates 4053198..4054499 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag SHEWMR4_RS17740 Protein ID WP_041408886.1
Coordinates 4054503..4054739 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SHEWMR4_RS17730 4051804..4052400 - 597 WP_011624126.1 hypothetical protein -
SHEWMR4_RS17735 4053198..4054499 - 1302 WP_011624127.1 type II toxin-antitoxin system toxin serine/threonine-protein kinase HipA Toxin
SHEWMR4_RS17740 4054503..4054739 - 237 WP_041408886.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
SHEWMR4_RS17745 4055174..4056811 - 1638 WP_011624129.1 chaperonin GroEL -
SHEWMR4_RS17750 4056869..4057159 - 291 WP_011071021.1 co-chaperone GroES -
SHEWMR4_RS17755 4057387..4058745 + 1359 WP_011624130.1 MATE family efflux transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(27-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48671.98 Da        Isoelectric Point: 6.0161

>T21684 WP_011624127.1 NC_008321:c4054499-4053198 [Shewanella sp. MR-4]
MSTAKTLTLEMHLGDSIIGELSFGATTDTFAVHYTKDWQQSGFPLSPTIPLDGTGTSNQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAIAFVPKGVLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GKEFAFAEGTLSSTHIVKFEKHHHLVINEFITMRLAKVIGMNVANVDIVHFGRYKALCVERFDRRYMSNEQRVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAAKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLGLPRNLLISNLTRIARKIPQAIAEVILMLPPLD
EDEASFVAHYKTQLLARCERYLGFVDEVRDVEV

Download         Length: 1302 bp

>T21684 NC_008321:c4054499-4053198 [Shewanella sp. MR-4]
ATGAGTACAGCTAAAACGCTTACGCTAGAGATGCACCTCGGTGATTCAATTATCGGGGAATTATCCTTTGGTGCCACGAC
CGACACCTTTGCCGTGCATTACACCAAAGACTGGCAGCAAAGTGGATTTCCACTTTCACCAACTATTCCCTTAGATGGCA
CAGGAACGAGTAATCAAATATCAATGTTTTTGGTTAACTTATTGCCAGAAAATAAAGGATTAGATTATCTGATTGAATCG
CTTGGCGTCTCTAAGGGGAACACCTTTGCCTTGATCCGCGCCATTGGTCTCGATACCGCAGGTGCCATCGCTTTCGTTCC
TAAAGGAGTTTTACTGCCTGAAACACAATTGCGGCCAATTAAGGCTGAAGAAGTTATTCAACGCATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGATGGTAAACCTCGACTATCGGTAGCGGGTGTTCAGCCTAAGTTAAACTTGTTTTATAAC
GGGAAAGAATTTGCCTTTGCCGAAGGTACGCTGTCATCGACCCATATTGTTAAATTCGAAAAACATCATCATTTAGTGAT
CAATGAATTTATAACGATGCGCTTAGCCAAAGTGATTGGGATGAATGTGGCGAATGTCGATATTGTTCATTTTGGCCGTT
ACAAAGCCCTTTGTGTTGAACGCTTCGACAGACGTTATATGTCAAATGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCCCTTGGTTTTAGTGTAAGCAAAAAATATGAACGTAATTTTGGTTCAGGGCGCGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTCTTTAGTCTTGCAGCAAAATGCCGTAATCCCGTGGCTGCTAAGCAAGACATGTTGC
AATGGGCGTTATTCAATTTACTGACTGGCAATGCCGATGCACACGGTAAAAACTACTCATTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCTATGGCTATTGA
TGACGAATTTGATCCAAATAGCATTTACGCGTATCAATTAGCCGCGTTTATAGATGGCTTGGGTTTACCAAGAAATCTAT
TAATCAGTAACTTAACGAGAATTGCGCGAAAAATACCGCAGGCAATAGCTGAGGTGATTTTAATGCTCCCGCCCCTTGAT
GAAGATGAAGCATCATTTGTGGCGCATTACAAAACCCAGTTACTAGCGAGATGTGAACGTTACCTTGGTTTTGTTGACGA
GGTCAGGGATGTGGAAGTGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8543.90 Da        Isoelectric Point: 6.2232

>AT21684 WP_041408886.1 NC_008321:c4054739-4054503 [Shewanella sp. MR-4]
MASPLNQQSLGLLIKERRKTAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVSVQTSDTETNGWY

Download         Length: 237 bp

>AT21684 NC_008321:c4054739-4054503 [Shewanella sp. MR-4]
ATGGCATCACCGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGCAGGAAAACTGCTGCTCTTACCCAAGACGT
GGCGGCCATGCTGTGTGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAGGGCGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGATATCGTTTCGGTTCAAACCAGCGACACTGAAACTAATGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References