Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 914926..915521 Replicon chromosome
Accession NZ_CP083610
Organism Escherichia coli strain EC2648-Vir1

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag LAJ48_RS04490 Protein ID WP_000239577.1
Coordinates 914926..915276 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LAJ48_RS04495 Protein ID WP_001223208.1
Coordinates 915270..915521 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ48_RS04470 (910372) 910372..911394 - 1023 WP_001313531.1 ABC transporter permease -
LAJ48_RS04475 (911408) 911408..912910 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
LAJ48_RS04480 (913050) 913050..914006 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LAJ48_RS04485 (914316) 914316..914846 + 531 WP_000055075.1 inorganic diphosphatase -
LAJ48_RS04490 (914926) 914926..915276 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
LAJ48_RS04495 (915270) 915270..915521 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LAJ48_RS04500 (915733) 915733..916074 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LAJ48_RS04505 (916077) 916077..919856 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T216828 WP_000239577.1 NZ_CP083610:c915276-914926 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T216828 NZ_CP113486:c5162717-5162523 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT216828 WP_001223208.1 NZ_CP083610:c915521-915270 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT216828 NZ_CP113486:5162346-5162524 [Escherichia coli]
GAGGACTGAAGTCTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGGCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References