Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 829915..830729 Replicon chromosome
Accession NZ_CP083610
Organism Escherichia coli strain EC2648-Vir1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag LAJ48_RS04060 Protein ID WP_001054376.1
Coordinates 829915..830172 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag LAJ48_RS04065 Protein ID WP_001309181.1
Coordinates 830184..830729 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ48_RS04035 (825203) 825203..826309 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
LAJ48_RS04040 (826374) 826374..827354 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
LAJ48_RS04045 (827464) 827464..827669 + 206 Protein_795 HNH endonuclease -
LAJ48_RS04050 (827937) 827937..829177 - 1241 Protein_796 helicase YjhR -
LAJ48_RS04055 (829293) 829293..829424 + 132 WP_001309182.1 hypothetical protein -
LAJ48_RS04060 (829915) 829915..830172 + 258 WP_001054376.1 YjhX family toxin Toxin
LAJ48_RS04065 (830184) 830184..830729 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
LAJ48_RS04070 (830785) 830785..831531 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
LAJ48_RS04075 (831700) 831700..831918 + 219 Protein_801 hypothetical protein -
LAJ48_RS04080 (831956) 831956..832072 + 117 Protein_802 VOC family protein -
LAJ48_RS04085 (832317) 832317..833438 + 1122 WP_000010829.1 M42 family metallopeptidase -
LAJ48_RS04090 (833435) 833435..833713 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
LAJ48_RS04095 (833725) 833725..835038 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 818925..838953 20028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T216827 WP_001054376.1 NZ_CP083610:829915-830172 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T216827 NZ_CP113486:c5024063-5023956 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT216827 WP_001309181.1 NZ_CP083610:830184-830729 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT216827 NZ_CP113486:5024110-5024176 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References