Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1929176..1929667 Replicon chromosome
Accession NZ_CP083604
Organism Macrococcus armenti strain JEK46

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LAU40_RS10415 Protein ID WP_224183481.1
Coordinates 1929176..1929526 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LAU40_RS10420 Protein ID WP_224183482.1
Coordinates 1929527..1929667 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU40_RS10390 (LAU40_10390) 1924290..1926425 - 2136 WP_224187185.1 Tex family protein -
LAU40_RS10395 (LAU40_10395) 1926500..1927267 - 768 WP_224183477.1 RNA polymerase sigma factor SigB -
LAU40_RS10400 (LAU40_10400) 1927272..1927715 - 444 WP_224187187.1 anti-sigma B factor RsbW -
LAU40_RS10405 (LAU40_10405) 1927721..1928044 - 324 WP_224183479.1 anti-sigma factor antagonist -
LAU40_RS10410 (LAU40_10410) 1928120..1929127 - 1008 WP_224183480.1 PP2C family protein-serine/threonine phosphatase -
LAU40_RS10415 (LAU40_10415) 1929176..1929526 - 351 WP_224183481.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LAU40_RS10420 (LAU40_10420) 1929527..1929667 - 141 WP_224183482.1 antitoxin MazE Antitoxin
LAU40_RS10425 (LAU40_10425) 1929729..1930871 - 1143 WP_224183483.1 alanine racemase -
LAU40_RS10430 (LAU40_10430) 1930912..1931253 - 342 WP_224183484.1 holo-ACP synthase -
LAU40_RS10435 (LAU40_10435) 1931195..1931719 - 525 WP_224187189.1 PH domain-containing protein -
LAU40_RS10440 (LAU40_10440) 1931703..1933214 - 1512 WP_224187191.1 PH domain-containing protein -
LAU40_RS10445 (LAU40_10445) 1933204..1933680 - 477 WP_224187193.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12717.88 Da        Isoelectric Point: 9.8410

>T216817 WP_224183481.1 NZ_CP083604:c1929526-1929176 [Macrococcus armenti]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKTSHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKVKMKEVDVALAISLGLSIESE

Download         Length: 351 bp

>T216817 NZ_CP113486:3378574-3378924 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5239.84 Da        Isoelectric Point: 3.8301

>AT216817 WP_224183482.1 NZ_CP083604:c1929667-1929527 [Macrococcus armenti]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTLALDGE

Download         Length: 141 bp

>AT216817 NZ_CP113486:3378329-3378580 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References