Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1929213..1929704 Replicon chromosome
Accession NZ_CP083602
Organism Macrococcus armenti strain JEK29

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LAU39_RS10440 Protein ID WP_224183481.1
Coordinates 1929213..1929563 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LAU39_RS10445 Protein ID WP_224183482.1
Coordinates 1929564..1929704 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU39_RS10415 (LAU39_10415) 1924327..1926462 - 2136 WP_224187185.1 Tex family protein -
LAU39_RS10420 (LAU39_10420) 1926537..1927304 - 768 WP_224183477.1 RNA polymerase sigma factor SigB -
LAU39_RS10425 (LAU39_10425) 1927309..1927752 - 444 WP_224187187.1 anti-sigma B factor RsbW -
LAU39_RS10430 (LAU39_10430) 1927758..1928081 - 324 WP_224183479.1 anti-sigma factor antagonist -
LAU39_RS10435 (LAU39_10435) 1928157..1929164 - 1008 WP_224183480.1 PP2C family protein-serine/threonine phosphatase -
LAU39_RS10440 (LAU39_10440) 1929213..1929563 - 351 WP_224183481.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LAU39_RS10445 (LAU39_10445) 1929564..1929704 - 141 WP_224183482.1 antitoxin MazE Antitoxin
LAU39_RS10450 (LAU39_10450) 1929766..1930908 - 1143 WP_224183483.1 alanine racemase -
LAU39_RS10455 (LAU39_10455) 1930949..1931290 - 342 WP_224183484.1 holo-ACP synthase -
LAU39_RS10460 (LAU39_10460) 1931232..1931756 - 525 WP_224187189.1 PH domain-containing protein -
LAU39_RS10465 (LAU39_10465) 1931740..1933251 - 1512 WP_224187191.1 PH domain-containing protein -
LAU39_RS10470 (LAU39_10470) 1933241..1933717 - 477 WP_224187193.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12717.88 Da        Isoelectric Point: 9.8410

>T216814 WP_224183481.1 NZ_CP083602:c1929563-1929213 [Macrococcus armenti]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKTSHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKVKMKEVDVALAISLGLSIESE

Download         Length: 351 bp

>T216814 NZ_CP113486:c2622538-2622353 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5239.84 Da        Isoelectric Point: 3.8301

>AT216814 WP_224183482.1 NZ_CP083602:c1929704-1929564 [Macrococcus armenti]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTLALDGE

Download         Length: 141 bp

>AT216814 NZ_CP113486:c2622336-2621926 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References