Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 1929084..1929575 | Replicon | chromosome |
| Accession | NZ_CP083598 | ||
| Organism | Macrococcus armenti strain JEK12 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | LAU44_RS10410 | Protein ID | WP_224183481.1 |
| Coordinates | 1929084..1929434 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | LAU44_RS10415 | Protein ID | WP_224183482.1 |
| Coordinates | 1929435..1929575 (-) | Length | 47 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LAU44_RS10385 (LAU44_10385) | 1924198..1926333 | - | 2136 | WP_224187185.1 | Tex family protein | - |
| LAU44_RS10390 (LAU44_10390) | 1926408..1927175 | - | 768 | WP_224183477.1 | RNA polymerase sigma factor SigB | - |
| LAU44_RS10395 (LAU44_10395) | 1927180..1927623 | - | 444 | WP_224187187.1 | anti-sigma B factor RsbW | - |
| LAU44_RS10400 (LAU44_10400) | 1927629..1927952 | - | 324 | WP_224183479.1 | anti-sigma factor antagonist | - |
| LAU44_RS10405 (LAU44_10405) | 1928028..1929035 | - | 1008 | WP_224183480.1 | PP2C family protein-serine/threonine phosphatase | - |
| LAU44_RS10410 (LAU44_10410) | 1929084..1929434 | - | 351 | WP_224183481.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LAU44_RS10415 (LAU44_10415) | 1929435..1929575 | - | 141 | WP_224183482.1 | antitoxin MazE | Antitoxin |
| LAU44_RS10420 (LAU44_10420) | 1929637..1930779 | - | 1143 | WP_224183483.1 | alanine racemase | - |
| LAU44_RS10425 (LAU44_10425) | 1930820..1931161 | - | 342 | WP_224183484.1 | holo-ACP synthase | - |
| LAU44_RS10430 (LAU44_10430) | 1931103..1931627 | - | 525 | WP_224187189.1 | PH domain-containing protein | - |
| LAU44_RS10435 (LAU44_10435) | 1931611..1933122 | - | 1512 | WP_224187191.1 | PH domain-containing protein | - |
| LAU44_RS10440 (LAU44_10440) | 1933112..1933588 | - | 477 | WP_224187193.1 | PH domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12717.88 Da Isoelectric Point: 9.8410
>T216811 WP_224183481.1 NZ_CP083598:c1929434-1929084 [Macrococcus armenti]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKTSHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKVKMKEVDVALAISLGLSIESE
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKTSHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKVKMKEVDVALAISLGLSIESE
Download Length: 351 bp
>T216811 NZ_CP113486:c2565886-2565779 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 47 a.a. Molecular weight: 5239.84 Da Isoelectric Point: 3.8301
>AT216811 WP_224183482.1 NZ_CP083598:c1929575-1929435 [Macrococcus armenti]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTLALDGE
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTLALDGE
Download Length: 141 bp
>AT216811 NZ_CP113486:2565934-2566000 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|