Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 142873..143564 Replicon chromosome
Accession NC_008319
Organism Synechococcus sp. CC9311

Toxin (Protein)


Gene name vapC Uniprot ID Q0IDV0
Locus tag SYNC_RS00705 Protein ID WP_011618120.1
Coordinates 142873..143319 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q0IDU9
Locus tag SYNC_RS00710 Protein ID WP_011618121.1
Coordinates 143319..143564 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SYNC_RS00685 138921..140168 - 1248 WP_011618117.1 beta-ketoacyl-ACP synthase II -
SYNC_RS00690 140177..140419 - 243 WP_038014040.1 acyl carrier protein -
SYNC_RS13635 140569..140814 + 246 WP_006042515.1 photosystem I iron-sulfur center protein PsaC -
SYNC_RS00700 140865..142751 + 1887 WP_011618119.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
SYNC_RS00705 142873..143319 - 447 WP_011618120.1 PIN domain-containing protein Toxin
SYNC_RS00710 143319..143564 - 246 WP_011618121.1 ribbon-helix-helix domain-containing protein Antitoxin
SYNC_RS00715 143772..144116 - 345 Protein_139 SLC13 family permease -
SYNC_RS00720 144595..145389 - 795 WP_011618124.1 glycosyltransferase family 2 protein -
SYNC_RS00725 145603..146352 - 750 WP_167897121.1 hypothetical protein -
SYNC_RS00730 146555..147379 - 825 WP_011618126.1 alpha-1,2-fucosyltransferase -
SYNC_RS14095 147550..148272 - 723 WP_011618127.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(6-135)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16283.58 Da        Isoelectric Point: 6.4924

>T21681 WP_011618120.1 NC_008319:c143319-142873 [Synechococcus sp. CC9311]
MAEPIALLDVNVLIALIDPQHVHHEPSHRWFQAHGGDGWATCPLTQNALLRILGNPRYPNSPGGPAVVMSFLQELLAHPA
HVFWPDALSWQATGVFEAEALLHHGQITDTYLLGLAVHHQGRLVSFDRRLSLRAVRGGEEALHLIDPG

Download         Length: 447 bp

>T21681 NC_008319:c143319-142873 [Synechococcus sp. CC9311]
ATGGCCGAACCGATTGCGTTGCTGGATGTGAATGTGCTGATCGCTTTGATCGATCCCCAGCATGTGCACCACGAGCCATC
CCACCGCTGGTTTCAGGCCCATGGCGGTGATGGCTGGGCGACATGCCCCCTCACTCAGAACGCGCTGTTACGAATTCTCG
GGAACCCGCGCTATCCCAACAGCCCTGGCGGGCCTGCTGTTGTGATGTCATTCCTCCAAGAACTGCTTGCCCATCCGGCT
CATGTTTTTTGGCCTGATGCGTTGTCCTGGCAGGCCACTGGAGTCTTTGAGGCAGAAGCACTTCTTCACCACGGGCAAAT
CACGGATACCTACCTTCTTGGGTTGGCAGTGCATCACCAAGGAAGGCTTGTCAGCTTTGACAGGCGCCTGAGCCTTCGTG
CTGTACGCGGGGGAGAAGAGGCGTTGCATTTGATTGATCCAGGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8792.90 Da        Isoelectric Point: 6.2977

>AT21681 WP_011618121.1 NC_008319:c143564-143319 [Synechococcus sp. CC9311]
MRTTLRLDDDVLAAARVLARQRRRSVGDVISDLARQTLSRPADGGSQNVLEQRSGLPQLPVKASGGAVDLELVNQLRDEE
A

Download         Length: 246 bp

>AT21681 NC_008319:c143564-143319 [Synechococcus sp. CC9311]
ATGCGTACGACCCTGCGGCTCGATGACGATGTGCTCGCCGCAGCGCGCGTATTGGCTCGTCAGCGTCGCCGTTCTGTGGG
CGATGTCATTAGCGACCTAGCCCGGCAGACCCTATCCAGGCCAGCAGACGGAGGGTCGCAGAACGTTTTGGAGCAACGCT
CCGGATTGCCGCAATTGCCTGTCAAAGCTTCTGGTGGGGCTGTTGATCTTGAGCTTGTCAATCAGCTTCGCGATGAAGAG
GCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q0IDV0

Antitoxin

Source ID Structure
AlphaFold DB Q0IDU9

References