216808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1904943..1905434 Replicon chromosome
Accession NZ_CP083595
Organism Macrococcus armenti strain 17Msa1131

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LAU43_RS10205 Protein ID WP_224185322.1
Coordinates 1904943..1905293 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LAU43_RS10210 Protein ID WP_224183482.1
Coordinates 1905294..1905434 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU43_RS10180 (LAU43_10180) 1900057..1902192 - 2136 WP_224185317.1 Tex family protein -
LAU43_RS10185 (LAU43_10185) 1902267..1903034 - 768 WP_224185318.1 RNA polymerase sigma factor SigB -
LAU43_RS10190 (LAU43_10190) 1903039..1903482 - 444 WP_224185319.1 anti-sigma B factor RsbW -
LAU43_RS10195 (LAU43_10195) 1903488..1903811 - 324 WP_224185320.1 anti-sigma factor antagonist -
LAU43_RS10200 (LAU43_10200) 1903887..1904894 - 1008 WP_224185321.1 PP2C family protein-serine/threonine phosphatase -
LAU43_RS10205 (LAU43_10205) 1904943..1905293 - 351 WP_224185322.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LAU43_RS10210 (LAU43_10210) 1905294..1905434 - 141 WP_224183482.1 antitoxin MazE Antitoxin
LAU43_RS10215 (LAU43_10215) 1905496..1906638 - 1143 WP_224185323.1 alanine racemase -
LAU43_RS10220 (LAU43_10220) 1906679..1907020 - 342 WP_224185324.1 holo-ACP synthase -
LAU43_RS10225 (LAU43_10225) 1906962..1907486 - 525 WP_224185325.1 PH domain-containing protein -
LAU43_RS10230 (LAU43_10230) 1907470..1908981 - 1512 WP_224185326.1 PH domain-containing protein -
LAU43_RS10235 (LAU43_10235) 1908971..1909447 - 477 WP_224185327.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12718.83 Da        Isoelectric Point: 9.8410

>T216808 WP_224185322.1 NZ_CP083595:c1905293-1904943 [Macrococcus armenti]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKNPTHVEIGKTSHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKVKMKEVDVALAISLGLSIESE

Download         Length: 351 bp

>T216808 NZ_CP113486:1871938-1872315 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5239.84 Da        Isoelectric Point: 3.8301

>AT216808 WP_224183482.1 NZ_CP083595:c1905434-1905294 [Macrococcus armenti]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTLALDGE

Download         Length: 141 bp

>AT216808 NZ_CP113486:1871480-1871848 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCATGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAAT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References