Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1938467..1938958 Replicon chromosome
Accession NZ_CP083594
Organism Macrococcus armenti strain 19Msa0295

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LAU38_RS10520 Protein ID WP_224183481.1
Coordinates 1938467..1938817 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LAU38_RS10525 Protein ID WP_224183482.1
Coordinates 1938818..1938958 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU38_RS10495 (LAU38_10495) 1933581..1935716 - 2136 WP_224199040.1 Tex family protein -
LAU38_RS10500 (LAU38_10500) 1935791..1936558 - 768 WP_224183477.1 RNA polymerase sigma factor SigB -
LAU38_RS10505 (LAU38_10505) 1936563..1937006 - 444 WP_224183478.1 anti-sigma B factor RsbW -
LAU38_RS10510 (LAU38_10510) 1937012..1937335 - 324 WP_224183479.1 anti-sigma factor antagonist -
LAU38_RS10515 (LAU38_10515) 1937411..1938418 - 1008 WP_224199042.1 PP2C family protein-serine/threonine phosphatase -
LAU38_RS10520 (LAU38_10520) 1938467..1938817 - 351 WP_224183481.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LAU38_RS10525 (LAU38_10525) 1938818..1938958 - 141 WP_224183482.1 antitoxin MazE Antitoxin
LAU38_RS10530 (LAU38_10530) 1939020..1940162 - 1143 WP_224183483.1 alanine racemase -
LAU38_RS10535 (LAU38_10535) 1940203..1940544 - 342 WP_224183484.1 holo-ACP synthase -
LAU38_RS10540 (LAU38_10540) 1940486..1941010 - 525 WP_224187189.1 PH domain-containing protein -
LAU38_RS10545 (LAU38_10545) 1940994..1942505 - 1512 WP_224187191.1 PH domain-containing protein -
LAU38_RS10550 (LAU38_10550) 1942495..1942971 - 477 WP_224187193.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12717.88 Da        Isoelectric Point: 9.8410

>T216806 WP_224183481.1 NZ_CP083594:c1938817-1938467 [Macrococcus armenti]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKTSHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKVKMKEVDVALAISLGLSIESE

Download         Length: 351 bp

>T216806 NZ_CP113486:c1615639-1615304 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5239.84 Da        Isoelectric Point: 3.8301

>AT216806 WP_224183482.1 NZ_CP083594:c1938958-1938818 [Macrococcus armenti]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTLALDGE

Download         Length: 141 bp

>AT216806 NZ_CP113486:c1615887-1615639 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References