Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1930767..1931258 Replicon chromosome
Accession NZ_CP083592
Organism Macrococcus armenti strain 19Msa0966

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LAU41_RS10320 Protein ID WP_224199043.1
Coordinates 1930767..1931117 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LAU41_RS10325 Protein ID WP_224183482.1
Coordinates 1931118..1931258 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU41_RS10295 (LAU41_10295) 1925881..1928016 - 2136 WP_224199040.1 Tex family protein -
LAU41_RS10300 (LAU41_10300) 1928091..1928858 - 768 WP_224183477.1 RNA polymerase sigma factor SigB -
LAU41_RS10305 (LAU41_10305) 1928863..1929306 - 444 WP_224183478.1 anti-sigma B factor RsbW -
LAU41_RS10310 (LAU41_10310) 1929312..1929635 - 324 WP_224199041.1 anti-sigma factor antagonist -
LAU41_RS10315 (LAU41_10315) 1929711..1930718 - 1008 WP_224199042.1 PP2C family protein-serine/threonine phosphatase -
LAU41_RS10320 (LAU41_10320) 1930767..1931117 - 351 WP_224199043.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LAU41_RS10325 (LAU41_10325) 1931118..1931258 - 141 WP_224183482.1 antitoxin MazE Antitoxin
LAU41_RS10330 (LAU41_10330) 1931320..1932462 - 1143 WP_224183483.1 alanine racemase -
LAU41_RS10335 (LAU41_10335) 1932503..1932844 - 342 WP_224183484.1 holo-ACP synthase -
LAU41_RS10340 (LAU41_10340) 1932786..1933310 - 525 WP_224187189.1 PH domain-containing protein -
LAU41_RS10345 (LAU41_10345) 1933294..1934805 - 1512 WP_224187191.1 PH domain-containing protein -
LAU41_RS10350 (LAU41_10350) 1934795..1935271 - 477 WP_224187193.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12747.97 Da        Isoelectric Point: 9.8410

>T216804 WP_224199043.1 NZ_CP083592:c1931117-1930767 [Macrococcus armenti]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKMSHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKVKMKEVDVALAISLGLSIESE

Download         Length: 351 bp

>T216804 NZ_CP113486:c732631-732380 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5239.84 Da        Isoelectric Point: 3.8301

>AT216804 WP_224183482.1 NZ_CP083592:c1931258-1931118 [Macrococcus armenti]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTLALDGE

Download         Length: 141 bp

>AT216804 NZ_CP113486:c732383-732129 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References