Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2881812..2882848 Replicon chromosome
Accession NZ_CP083589
Organism Herbaspirillum frisingense strain AU14559

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag LAZ82_RS13000 Protein ID WP_234293712.1
Coordinates 2882273..2882848 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag LAZ82_RS12995 Protein ID WP_006712983.1
Coordinates 2881812..2882276 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAZ82_RS12970 (LAZ82_12970) 2877429..2878037 - 609 WP_006712974.1 dTMP kinase -
LAZ82_RS12975 (LAZ82_12975) 2878080..2879060 - 981 WP_234293709.1 endolytic transglycosylase MltG -
LAZ82_RS12980 (LAZ82_12980) 2879204..2880261 + 1058 Protein_2560 folate-binding protein -
LAZ82_RS12985 (LAZ82_12985) 2880296..2880595 + 300 WP_234293710.1 DUF4936 family protein -
LAZ82_RS12990 (LAZ82_12990) 2880586..2881434 + 849 WP_234293711.1 NRDE family protein -
LAZ82_RS12995 (LAZ82_12995) 2881812..2882276 + 465 WP_006712983.1 helix-turn-helix domain-containing protein Antitoxin
LAZ82_RS13000 (LAZ82_13000) 2882273..2882848 + 576 WP_234293712.1 PIN domain-containing protein Toxin
LAZ82_RS13005 (LAZ82_13005) 2882983..2884308 - 1326 WP_234293713.1 dicarboxylate/amino acid:cation symporter -
LAZ82_RS13010 (LAZ82_13010) 2884606..2886183 + 1578 WP_234293714.1 methyl-accepting chemotaxis protein -
LAZ82_RS13015 (LAZ82_13015) 2886219..2886647 - 429 WP_234293715.1 GNAT family N-acetyltransferase -
LAZ82_RS13020 (LAZ82_13020) 2886710..2887144 - 435 WP_039876442.1 PaaI family thioesterase -
LAZ82_RS13025 (LAZ82_13025) 2887155..2887457 - 303 WP_182992104.1 Dabb family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

SinI-like, DNA-binding domain

(83-129)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21395.59 Da        Isoelectric Point: 7.2205

>T216801 WP_234293712.1 NZ_CP083589:2882273-2882848 [Herbaspirillum frisingense]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGLFRARWSRAIHEEWKRNLLIKRPDLTRTQLDRTSALMDRAIPDSLVEGH
EALVAGLHLPDPDDRHVLAAAIRCGASVIVTFNERDFPAQVLAPYGIEAQHPDEFAHNLLDLDAAAVAAAAQRQRAQLKN
PPVDVDHYLDILLRQGLAHTAKALRAYRAVL

Download         Length: 576 bp

>T216801 NZ_CP113486:c528670-528567 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 16968.32 Da        Isoelectric Point: 5.9195

>AT216801 WP_006712983.1 NZ_CP083589:2881812-2882276 [Herbaspirillum frisingense]
MTPSAATMSLPAAKDVELAVRGQRALAAYLSTQVDTQHIQIFDAQNRAHEVELPTSALRLLVEILAELADGNAVKVVPVH
AELTTQEAADLLNVSRPHFVKLLEDGVIPFHRAGKHRRVKFADLMQYKTEREQASTEAMADLARQSQELGLGYE

Download         Length: 465 bp

>AT216801 NZ_CP113486:528529-528800 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References