Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 2798711..2799254 Replicon chromosome
Accession NC_008314
Organism Ralstonia eutropha H16

Toxin (Protein)


Gene name relE Uniprot ID Q0JYB8
Locus tag H16_RS31035 Protein ID WP_011617903.1
Coordinates 2798711..2799001 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R7XLV2
Locus tag H16_RS31040 Protein ID WP_010810750.1
Coordinates 2798988..2799254 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H16_RS31025 2795307..2796842 + 1536 WP_010810746.1 amino acid permease -
H16_RS31030 2796923..2798599 + 1677 WP_037024735.1 amidohydrolase family protein -
H16_RS31035 2798711..2799001 - 291 WP_011617903.1 type II toxin-antitoxin system YafQ family toxin Toxin
H16_RS31040 2798988..2799254 - 267 WP_010810750.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H16_RS31045 2799536..2801698 + 2163 WP_011617904.1 TonB-dependent receptor -
H16_RS31050 2801755..2802732 - 978 WP_010810752.1 tripartite tricarboxylate transporter substrate binding protein -
H16_RS31055 2802816..2803631 - 816 WP_011617905.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2751899..2799254 47355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11214.01 Da        Isoelectric Point: 10.0499

>T21680 WP_011617903.1 NC_008314:c2799001-2798711 [Cupriavidus necator H16]
MRTIERTTQFKRDYKRELKGPFKALLQSPAGDWFAILTALASDMSLPDKFRDHALGGQWKDFRDCHVRPDLLLIYRKPDP
WTLQLVRLGSHSELAM

Download         Length: 291 bp

>T21680 NC_008314:c2799001-2798711 [Cupriavidus necator H16]
ATGAGGACGATTGAACGGACGACCCAATTCAAGCGCGATTACAAGCGCGAACTCAAAGGGCCGTTCAAGGCGCTGCTGCA
AAGCCCGGCTGGTGACTGGTTTGCAATCCTGACTGCCTTGGCGAGTGACATGTCGCTGCCGGACAAATTTCGCGACCATG
CGCTTGGCGGCCAGTGGAAGGACTTCCGGGATTGCCATGTTCGGCCAGACCTTTTGCTGATCTATCGGAAGCCAGACCCT
TGGACACTGCAACTTGTCCGGCTTGGGTCGCATAGCGAGCTGGCCATGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9489.96 Da        Isoelectric Point: 4.4692

>AT21680 WP_010810750.1 NC_008314:c2799254-2798988 [Cupriavidus necator H16]
MSASTFVRARIDVEIKEEAAIVLEAMGLTVSDAVRMLLTRVAREKALPVELMTPNPATIASLKEARAGGLRKFGSVSDLM
ADLNDEDD

Download         Length: 267 bp

>AT21680 NC_008314:c2799254-2798988 [Cupriavidus necator H16]
ATGTCCGCTTCGACCTTTGTCCGAGCCCGTATCGACGTTGAAATCAAGGAAGAGGCCGCGATCGTTCTGGAAGCGATGGG
ACTGACGGTTTCAGACGCCGTGCGCATGCTTTTGACGCGCGTGGCACGTGAAAAGGCATTGCCTGTGGAACTGATGACTC
CCAATCCAGCAACCATTGCGTCGCTAAAAGAGGCGCGGGCCGGTGGCCTCCGCAAGTTCGGGTCGGTGAGCGACCTGATG
GCGGATCTCAACGATGAGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4G011

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4FZW4

References