Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4304076..4304910 Replicon chromosome
Accession NZ_CP083585
Organism Escherichia coli strain ECNB21-M121

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag LA372_RS20835 Protein ID WP_089613745.1
Coordinates 4304533..4304910 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LA372_RS20830 Protein ID WP_089613744.1
Coordinates 4304076..4304444 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA372_RS20795 (4299807) 4299807..4300691 + 885 WP_224204954.1 50S ribosome-binding GTPase -
LA372_RS20800 (4300810) 4300810..4301487 + 678 WP_001097362.1 hypothetical protein -
LA372_RS20805 (4301493) 4301493..4301726 + 234 WP_001278281.1 DUF905 family protein -
LA372_RS20810 (4301825) 4301825..4302643 + 819 WP_001234693.1 DUF932 domain-containing protein -
LA372_RS20815 (4302735) 4302735..4303220 + 486 WP_000206660.1 antirestriction protein -
LA372_RS20820 (4303236) 4303236..4303712 + 477 WP_074503008.1 RadC family protein -
LA372_RS20825 (4303775) 4303775..4303996 + 222 WP_000692323.1 DUF987 domain-containing protein -
LA372_RS20830 (4304076) 4304076..4304444 + 369 WP_089613744.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LA372_RS20835 (4304533) 4304533..4304910 + 378 WP_089613745.1 TA system toxin CbtA family protein Toxin
LA372_RS20840 (4304907) 4304907..4305395 + 489 WP_089613746.1 DUF5983 family protein -
LA372_RS20845 (4305407) 4305407..4305604 + 198 WP_089613747.1 DUF957 domain-containing protein -
LA372_RS20850 (4305689) 4305689..4306555 + 867 WP_032251878.1 DUF4942 domain-containing protein -
LA372_RS20855 (4306627) 4306627..4306890 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
LA372_RS20860 (4306887) 4306887..4307213 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
LA372_RS20865 (4307962) 4307962..4308659 + 698 WP_103215986.1 IS1-like element IS1A family transposase -
LA372_RS20870 (4308848) 4308848..4309120 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LA372_RS20875 (4309132) 4309132..4309362 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4284246..4308659 24413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14287.35 Da        Isoelectric Point: 9.7064

>T216795 WP_089613745.1 NZ_CP083585:4304533-4304910 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTGQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKR

Download         Length: 378 bp

>T216795 NZ_CP113485:1213440-1213811 [Mycobacterium avium subsp. paratuberculosis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTCGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13648.42 Da        Isoelectric Point: 7.7474

>AT216795 WP_089613744.1 NZ_CP083585:4304076-4304444 [Escherichia coli]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQESNQLHYLANRAGIRGRFSDADAYHLDQTFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp

>AT216795 NZ_CP113485:1213247-1213453 [Mycobacterium avium subsp. paratuberculosis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGGCACCCGCCGATGATTCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References