Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2823209..2824053 Replicon chromosome
Accession NZ_CP083585
Organism Escherichia coli strain ECNB21-M121

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag LA372_RS13710 Protein ID WP_000854686.1
Coordinates 2823209..2823592 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag LA372_RS13715 Protein ID WP_001285602.1
Coordinates 2823673..2824053 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA372_RS13670 (2818212) 2818212..2818703 - 492 WP_001300785.1 DUF1097 domain-containing protein -
LA372_RS13675 (2818805) 2818805..2819359 - 555 WP_032223624.1 molecular chaperone YcdY -
LA372_RS13680 (2819383) 2819383..2820120 - 738 WP_000283664.1 zinc-binding phosphatase -
LA372_RS13685 (2820175) 2820175..2821113 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
LA372_RS13695 (2821584) 2821584..2822425 - 842 Protein_2686 DUF4942 domain-containing protein -
LA372_RS13700 (2822510) 2822510..2822707 - 198 WP_000839253.1 DUF957 domain-containing protein -
LA372_RS13705 (2822724) 2822724..2823212 - 489 WP_032180032.1 DUF5983 family protein -
LA372_RS13710 (2823209) 2823209..2823592 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
LA372_RS13715 (2823673) 2823673..2824053 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LA372_RS13720 (2824064) 2824064..2824747 - 684 WP_000086768.1 hypothetical protein -
LA372_RS13725 (2824766) 2824766..2824987 - 222 WP_000692298.1 DUF987 domain-containing protein -
LA372_RS13730 (2825050) 2825050..2825526 - 477 WP_001186726.1 RadC family protein -
LA372_RS13735 (2825542) 2825542..2826027 - 486 WP_000214307.1 antirestriction protein -
LA372_RS13740 (2826119) 2826119..2826940 - 822 WP_001761104.1 DUF932 domain-containing protein -
LA372_RS13745 (2827041) 2827041..2827249 - 209 Protein_2696 DUF905 domain-containing protein -
LA372_RS13750 (2827350) 2827350..2827805 - 456 WP_000581506.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T216787 WP_000854686.1 NZ_CP083585:c2823592-2823209 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T216787 NZ_CP113440:1558851-1559696 [Streptococcus macedonicus]
ATGAACAAAGCTAAATTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTCATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAAAGTTCTTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TTTCGAATGTCATCGGAGTTGAATCTCGTAGCACTGTTGATATTGACTTTTTATTCCATCAAATAACACTCTCAGAAGAA
ACTGTTAAACAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCCAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAGAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAACAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT216787 WP_001285602.1 NZ_CP083585:c2824053-2823673 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT216787 NZ_CP113440:1558264-1558854 [Streptococcus macedonicus]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGAATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACAGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCTAA
TCTAAATATTCACTTTGTCTCTAAAGAATACAGCGAGCTGGGAATGACTACTGTACCTACTCCTTTGGGAAACAACGTAA
GGGTATATGATTTTGAACGTATTATTTGTGATTTTGTAATACATCGAGAAAAGATTGATTCCGAACTCTTTGTCAAGACA
CTTCAATCTTATGGGAACTATCCTAAAAAAAATCTAGCAAAACTCTATGAATATGCGACAAAAATGAATACTTTAGAAAA
AGTTAAACAAACTCTGGAGGTTCTAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References