Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2356430..2358018 Replicon chromosome
Accession NZ_CP083585
Organism Escherichia coli strain ECNB21-M121

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LA372_RS11465 Protein ID WP_224205049.1
Coordinates 2356696..2358018 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LA372_RS11460 Protein ID WP_001296726.1
Coordinates 2356430..2356696 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA372_RS11460 (2356430) 2356430..2356696 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LA372_RS11465 (2356696) 2356696..2358018 + 1323 WP_224205049.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
LA372_RS11470 (2358289) 2358289..2358558 + 270 Protein_2245 AraC family transcriptional regulator -
LA372_RS11475 (2358992) 2358992..2359555 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
LA372_RS11480 (2359916) 2359916..2360626 + 711 WP_001195165.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49303.96 Da        Isoelectric Point: 8.8753

>T216785 WP_224205049.1 NZ_CP083585:2356696-2358018 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSNAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

>T216785 NZ_CP113439:c3367673-3367377 [Legionella pneumophila]
ATGATTTATGAGCTTCATTTTCATCCTTTAGCTTTAAAAGAATGGAAAAAGCTGGGGAAAAACCTTCAAGAAGAATTTAA
GAAAGTGTTAAAACGCCGTTTAGAAAATCCACATGTGGCTTCGGCTGGCTTAAGAGGCTCTTTAAAAAATTGCTATAAAA
TAAAATTACGTCAATCTGGTTATCGTTTGGTGTATCAAGTTAATGATAATAAATTAATTGTAACCGTCATAGCAGTCGGG
AAAAGAAACAAAAATGTTGTCTATGATGATGCAGATAACCGACAAGAAGACAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT216785 WP_001296726.1 NZ_CP083585:2356430-2356696 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp

>AT216785 NZ_CP113439:c3367914-3367663 [Legionella pneumophila]
ATGCAAACTTTATTTGCTACACAAGTAGCAAGCATTAGTGAATTAAAAAAGAACCCCACTAAGCTCATTAATGATGCTCA
TGGAAAACCTGTTGCTATTCTTAACCACAATACAGCAGCAGCATATTTAATTCCTGTTGAAACATTTGAAAAACTAATGG
ATTTGATTGATGAGAATGAACTACATAAAATAGTAGAAGAGCGTTTGTCAGCACCTTTTACCTCAATAAAGGTAAATATT
GATGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References