Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 998285..998868 Replicon chromosome
Accession NZ_CP083585
Organism Escherichia coli strain ECNB21-M121

Toxin (Protein)


Gene name mazF Uniprot ID S1EZP4
Locus tag LA372_RS04925 Protein ID WP_000254738.1
Coordinates 998533..998868 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag LA372_RS04920 Protein ID WP_000581937.1
Coordinates 998285..998533 (+) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA372_RS04910 (994624) 994624..995925 + 1302 WP_000046821.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
LA372_RS04915 (995973) 995973..998207 + 2235 WP_000226815.1 GTP pyrophosphokinase -
LA372_RS04920 (998285) 998285..998533 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LA372_RS04925 (998533) 998533..998868 + 336 WP_000254738.1 endoribonuclease MazF Toxin
LA372_RS04930 (998939) 998939..999730 + 792 WP_001071643.1 nucleoside triphosphate pyrophosphohydrolase -
LA372_RS04935 (999958) 999958..1001595 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
LA372_RS04940 (1001683) 1001683..1002981 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-109)

Antitoxin

(7-51)


Sequences


Toxin        


Download         Length: 112 a.a.        Molecular weight: 12098.04 Da        Isoelectric Point: 8.2618

>T216775 WP_000254738.1 NZ_CP083585:998533-998868 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

>T216775 NZ_CP113432:1846543-1847112 [Pseudomonas sp. ZM23]
ATGTTCAGACCGTTACCCATCACCTTGCAGCGCGGGGCCTTGCGCCTGGAGCCAATGGTGGAGGCCGACGTGCCGGAACT
GGTGACGCTGGCGGAAGCGAACCGCGAGGTGCTGCAGTTCATGAGCGCGCCACAGCGCCCGGACTGGTATCGCCAGGGCC
TTGCGGAGCAGCGTGATGGCCGCGCGCTACCGTTGGTCGTACGGCTGGGCAACCGGATCGTCGGTACCACGCGCTTCATG
GACTTCCTCCCGGCGCTGCCGGCCTGCGAGATCGGCGCCACCTGGCTGGACCAGGAGCAGCATGGCCGCGGCCTGAATGC
CACCATGAAGTACCTGATGCTGCGTCATGCCTTCGATAGCTGGAAGATGGTCCGCGTACAGTTCAAGACCGCCGCCAGCA
ATCAGCGCGGCCAGCGCTCTATCGAGAAGCTCGGCGCAGTGCGCGAAGGCGTGCTGCGCAATCATCGCCGGCTGGCTGGC
GGGCGCCTCGACGACACCATCCTCTACAGCATCACCGATCATGAGTGGCCACAGGTGAAGGCCGCGCTCGAGGCTGGTTT
CTCCGGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT216775 WP_000581937.1 NZ_CP083585:998285-998533 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp

>AT216775 NZ_CP113432:1847169-1848020 [Pseudomonas sp. ZM23]
ATGGCACAAGGCAACGCGAGCGGTGAGAAGACACGGTTCTGGCGGGCCCAGGAGCTGGGTGGCGTCGAGCTGCTGCATGC
ACGCTACATCGAGCAGGTGTTCTCGCCCCACGTCCATGAAGGCTTCGCCTTCGTCATGATCGAGCAGGGTGCGCAGCGCT
TCCACCATCGCGGCGCCGAGCACTTCGCGCCGTCGGGTAGCGTGGTGCTGATCAACCCCGACGAGGTTCACACCGGCTCC
AAGGCCGACGACGCCGGCTGGCGTTACCGAGGTTTCTACCCGGAGCTGGCGCAGGTCTCCGGCGTGCTGGAGGAGCTGGA
GCTGGGCAGAGGCGGCACGCCGTCGTTCGACGCCAGTGTGGTGTTCAATCCGGAGCTGGTGCAGGCGCTGTTCGCGGCTC
ACCGCCTGGTGGACTCCGACGCCAGCGTGCTACAGCGCCAGACTTGCTGGCGCGAGGCGCTCCTGCTGCTGTTCCAGCGT
CACGCGCGGATTCCCGAAGCGCCACCGGCTGGCAACGAACCGGTGGCCGTGGCGCGCGCCCGCGAACTGCTAGGCTCGCG
GCTGATGGAGCCGCCATCGCTGGAGGAACTGGCCGCTGCCGTCGGCCTGTCGCCGTTCCACTTCGCCCGCGTGTTCCGCA
AGGCCACCGGCCTGCCGCCCCACGCCTGGCTCAAGCAGCGCCGACTGGAACAGGCGAGGGCGCTGCTCAAGCAGGGCTGC
ATGCCGGTAAACGTGGCGACGCAGTTGGGCTTCGCCGACCAGAGCCACCTCAGCCGGCAGTTCAAGCAGGCTTATGGCGT
CGGTCCTGGCGAGTACCGCCAGGCGTGCGCTCGGTCGTTCCGCTCGGTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CK9
PDB 5CKH
PDB 5CO7
PDB 3NFC
PDB 5CR2
PDB 5CKB
PDB 5CQY
PDB 5CKD
PDB 5CKE
PDB 5CKF


Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References