Detailed information of TA system TA216765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 4379387..4379991
• Replicon: chromosome
• Accession: NZ_CP083582
• Organism: Kovacikia minuta CCNUW1 strain CCNU0001

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K9N68_RS20580
• Protein ID: WP_224340236.1
• Coordinates: 4379387..4379764 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K9N68_RS20585
• Protein ID: WP_224340237.1
• Coordinates: 4379773..4379991 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9N68_RS20560 (K9N68_20560)	4374927..4375259	+	333	WP_224340232.1	DUF565 domain-containing protein	-
K9N68_RS20565 (K9N68_20565)	4375265..4377157	+	1893	WP_224340233.1	aminopeptidase P family protein	-
K9N68_RS20570 (K9N68_20570)	4377225..4377812	-	588	WP_224340234.1	Uma2 family endonuclease	-
K9N68_RS20575 (K9N68_20575)	4377890..4379170	-	1281	WP_224340235.1	serine--tRNA ligase	-
K9N68_RS20580 (K9N68_20580)	4379387..4379764	-	378	WP_224340236.1	type II toxin-antitoxin system VapC family toxin	Toxin
K9N68_RS20585 (K9N68_20585)	4379773..4379991	-	219	WP_224340237.1	DUF2281 domain-containing protein	Antitoxin
K9N68_RS20590 (K9N68_20590)	4380014..4381057	-	1044	WP_224340238.1	paraslipin	-
K9N68_RS20595 (K9N68_20595)	4381156..4381371	-	216	WP_224340239.1	hypothetical protein	-
K9N68_RS20600 (K9N68_20600)	4381534..4382574	-	1041	WP_224340240.1	hypothetical protein	-
K9N68_RS20605 (K9N68_20605)	4382607..4383710	-	1104	WP_224340241.1	class I SAM-dependent methyltransferase	-
K9N68_RS20610 (K9N68_20610)	4383717..4384754	-	1038	WP_224340242.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (2-124)

Antitoxin

• Domain of unknown function DUF2281 (6-71)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14221.59 Da
• Isoelectric Point: 5.0092

>T216765 WP_224340236.1 NZ_CP083582:c4379764-4379387 [Kovacikia minuta CCNUW1]
MLLDTHTLLWFLNNEFKLPASIKQQIENTEFVFASIASIWEIAIKVNVGKLTLLSPLETIQLNMVALSIQELTISFADVQ
CYINLPLHHRDPFDRMLIAQAINHSLVIVSADTAFDAYPIQRVWA

Nucleotide

• Length: 378 bp

>T216765 NZ_CP113364:c4247244-4246753 [Salmonella enterica subsp. enterica]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8352.74 Da
• Isoelectric Point: 4.5859

>AT216765 WP_224340237.1 NZ_CP083582:c4379991-4379773 [Kovacikia minuta CCNUW1]
MIQPAILKKLESLPEPLQLKVLHYIDSLIEEQDKTSKQENAPKKYRVAGTMKGMIIMSDDFDEPLEDLKDYM

Nucleotide

• Length: 219 bp

>AT216765 NZ_CP113364:c4247534-4247241 [Salmonella enterica subsp. enterica]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA