216763

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1450128..1451047 Replicon chromosome
Accession NZ_CP083580
Organism Bacillus sp. PM8313

Toxin (Protein)


Gene name spoIISA Uniprot ID M5PDF4
Locus tag K9N56_RS07365 Protein ID WP_006638546.1
Coordinates 1450301..1451047 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7Y8RVI2
Locus tag K9N56_RS07360 Protein ID WP_029418621.1
Coordinates 1450128..1450301 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9N56_RS07340 (K9N56_07340) 1445575..1446672 + 1098 WP_006638551.1 mannonate dehydratase -
K9N56_RS07345 (K9N56_07345) 1446648..1447496 + 849 WP_006638550.1 SDR family oxidoreductase -
K9N56_RS07350 (K9N56_07350) 1447516..1448532 + 1017 WP_006638549.1 zinc-binding alcohol dehydrogenase family protein -
K9N56_RS07355 (K9N56_07355) 1448560..1449828 + 1269 WP_006638548.1 MFS transporter -
K9N56_RS07360 (K9N56_07360) 1450128..1450301 - 174 WP_029418621.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
K9N56_RS07365 (K9N56_07365) 1450301..1451047 - 747 WP_006638546.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
K9N56_RS07370 (K9N56_07370) 1451160..1452158 - 999 WP_006638545.1 inorganic phosphate transporter -
K9N56_RS07375 (K9N56_07375) 1452171..1452788 - 618 WP_006638544.1 DUF47 domain-containing protein -
K9N56_RS07380 (K9N56_07380) 1453116..1454876 + 1761 WP_006638543.1 gamma-glutamyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29647.11 Da        Isoelectric Point: 4.6172

>T216763 WP_006638546.1 NZ_CP083580:c1451047-1450301 [Bacillus sp. PM8313]
MLLFYQFSVWVIVLALALYVFAVWRFEKKMKEKTIAIRKTWYLLYVIGAVIYWTYNPQSLFTDPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSNELATDTRELLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGDIEAYAEGIEKLIKRFAEKMNISASL
CEYNSEQSKDHLLEHMENRFAVQEKLERKDVYYEENGKMVLIPFSIHEYDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PYEEEGDE

Download         Length: 747 bp

>T216763 NZ_CP113364:c4060811-4060503 [Salmonella enterica subsp. enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6961.93 Da        Isoelectric Point: 10.7390

>AT216763 WP_029418621.1 NZ_CP083580:c1450301-1450128 [Bacillus sp. PM8313]
MEPVFQHDEDRSIKRGAWKVFKKQSRTNIAKYELSPHTERIFRQNARLIDEYKRKNA

Download         Length: 174 bp

>AT216763 NZ_CP113364:c4061053-4060814 [Salmonella enterica subsp. enterica]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGCGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M5PDF4

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y8RVI2

References