Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 19633..20126 Replicon plasmid pXAM38
Accession NZ_CP083576
Organism Xanthomonas phaseoli pv. manihotis strain CHN01

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K9838_RS22000 Protein ID WP_017157754.1
Coordinates 19633..19959 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag K9838_RS22005 Protein ID WP_017157755.1
Coordinates 19956..20126 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9838_RS21985 (K9838_21975) 14812..15000 + 189 WP_017163113.1 hypothetical protein -
K9838_RS21990 (K9838_21980) 15004..16578 + 1575 WP_017171346.1 type IV secretion system DNA-binding domain-containing protein -
K9838_RS21995 (K9838_21985) 16601..19576 + 2976 WP_017163114.1 MobF family relaxase -
K9838_RS22000 (K9838_21990) 19633..19959 - 327 WP_017157754.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K9838_RS22005 (K9838_21995) 19956..20126 - 171 WP_017157755.1 antitoxin MazE family protein Antitoxin
K9838_RS22010 (K9838_22000) 20371..20652 + 282 WP_017157756.1 DUF1778 domain-containing protein -
K9838_RS22015 (K9838_22005) 20649..21146 + 498 WP_017157757.1 GNAT family N-acetyltransferase -
K9838_RS22020 (K9838_22010) 21519..22559 + 1041 WP_033480827.1 IS21 family transposase -
K9838_RS22025 (K9838_22015) 22559..23359 + 801 WP_134979638.1 IS21-like element helper ATPase IstB -
K9838_RS22030 (K9838_22020) 23645..24058 - 414 WP_017163243.1 hypothetical protein -
K9838_RS22035 (K9838_22025) 24069..24644 - 576 WP_017157760.1 phospholipase D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..39414 39414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(2-54)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11733.75 Da        Isoelectric Point: 9.2550

>T216761 WP_017157754.1 NZ_CP083576:c19959-19633 [Xanthomonas phaseoli pv. manihotis]
MMRGDFVTIAMQGDFGKPRPALVIQANQFDEHTTVTVLPVTSTLVAAPLLRITVHPSTDNGLQKPSQVMVDKAMTVKRDK
VGRAFGRVDADALVEIERCLAVFLGIAK

Download         Length: 327 bp

>T216761 NZ_CP113364:3584781-3585008 [Salmonella enterica subsp. enterica]
ATGACCACCTGTTACTCACAAATCCCCAGCCAGCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCA
CGGCGTCACCGTGAAGATCTCCGAGGGGTGTTTGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGC
TTTATCAGGTGAAAAAGTCGATGAAGCATATTAAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6518.34 Da        Isoelectric Point: 4.1476

>AT216761 WP_017157755.1 NZ_CP083576:c20126-19956 [Xanthomonas phaseoli pv. manihotis]
MAGLRPVQIWVPDTRRPDFAEECRRQCRLAAQADMADTDMQRFMDEALADMDGWTE

Download         Length: 171 bp

>AT216761 NZ_CP113364:c3584998-3584587 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References