Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-TIGR02293
Location 1420291..1421276 Replicon chromosome
Accession NC_008314
Organism Ralstonia eutropha H16

Toxin (Protein)


Gene name ParT Uniprot ID Q0K1S1
Locus tag H16_RS25060 Protein ID WP_011617110.1
Coordinates 1420803..1421276 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID Q0K1S2
Locus tag H16_RS25055 Protein ID WP_011617109.1
Coordinates 1420291..1420806 (+) Length 172 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H16_RS25030 1415731..1416375 + 645 WP_010809399.1 TetR/AcrR family transcriptional regulator -
H16_RS34545 1416691..1417002 + 312 WP_011617106.1 hypothetical protein -
H16_RS25035 1417080..1417262 + 183 WP_010809397.1 hypothetical protein -
H16_RS25040 1417315..1417740 - 426 WP_035823937.1 hypothetical protein -
H16_RS25045 1417987..1419114 - 1128 WP_041688081.1 site-specific integrase -
H16_RS25050 1419228..1420193 + 966 WP_011617108.1 DNA-binding protein -
H16_RS25055 1420291..1420806 + 516 WP_011617109.1 DUF2384 domain-containing protein Antitoxin
H16_RS25060 1420803..1421276 + 474 WP_011617110.1 RES family NAD+ phosphorylase Toxin
H16_RS25065 1421280..1422857 - 1578 WP_011617111.1 fatty acid--CoA ligase -
H16_RS25070 1423090..1425360 + 2271 WP_041688083.1 ATP-dependent DNA helicase -
H16_RS25075 1425485..1425808 + 324 WP_010809389.1 thioredoxin family protein -
H16_RS25080 1425826..1426257 - 432 WP_010809388.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(4-152)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(44-105)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 16706.95 Da        Isoelectric Point: 6.2220

>T21676 WP_011617110.1 NC_008314:1420803-1421276 [Cupriavidus necator H16]
VRPAWRIATDTPDYTADDASGAGAKATGGRWNRQGTPLIYAASSIALACLETLVHLGSGGLPLNRYLVRIDIPDELWAAA
QKLSVDTAPVGWDAIPAGKTSLDTGEAWTAGGTSALLLVPSIVIPEEHNVLVNPAHPDAARLAYVKVRRWQYDARLV

Download         Length: 474 bp

>T21676 NC_008314:1420803-1421276 [Cupriavidus necator H16]
GTGAGGCCAGCCTGGCGGATCGCGACCGACACCCCAGACTACACCGCCGACGACGCCAGCGGCGCCGGCGCCAAGGCCAC
CGGCGGGCGCTGGAACCGGCAGGGCACGCCCTTGATTTATGCGGCGTCCAGCATCGCGCTGGCTTGCCTGGAAACGCTGG
TCCACCTGGGTTCAGGCGGGCTGCCGCTGAACCGCTACCTGGTCCGGATCGACATCCCCGACGAGCTATGGGCGGCTGCG
CAGAAACTGAGCGTCGACACCGCCCCCGTAGGCTGGGATGCCATTCCCGCCGGAAAGACCAGCCTCGACACCGGCGAAGC
CTGGACCGCCGGGGGCACCAGCGCCTTGCTGCTGGTGCCTTCCATCGTCATCCCTGAAGAGCACAACGTGCTGGTCAACC
CGGCGCACCCCGACGCCGCGCGGCTGGCTTACGTCAAGGTCCGCCGCTGGCAGTACGACGCGCGCCTGGTCTGA

Antitoxin


Download         Length: 172 a.a.        Molecular weight: 18518.17 Da        Isoelectric Point: 9.5015

>AT21676 WP_011617109.1 NC_008314:1420291-1420806 [Cupriavidus necator H16]
MPLMLTPKGRYPLAHERPAPPELGVNNYVAVYEASLSTQGAMSIIRAIREGVPASDLNRLAESMGTTKEQLIKTLDLPRA
TVDRKARAHQNLSSEQSERVLGMARLVGQVQALVESSGDPRGFSAAQWVAQWLEQPSPALGGRRPAELMDTLAGQRIVSD
LVARMQSGAYA

Download         Length: 516 bp

>AT21676 NC_008314:1420291-1420806 [Cupriavidus necator H16]
ATGCCGCTCATGCTCACTCCCAAAGGCCGCTATCCGCTGGCTCATGAACGCCCGGCTCCGCCCGAGCTGGGCGTCAACAA
CTACGTCGCCGTCTATGAGGCCAGCCTGTCGACGCAAGGCGCCATGTCGATCATCCGCGCGATTCGTGAAGGTGTGCCGG
CTTCAGACCTGAACCGCCTGGCCGAATCCATGGGCACCACCAAGGAGCAGCTGATCAAGACACTGGACTTGCCCCGCGCC
ACCGTGGACCGCAAGGCACGGGCGCACCAGAACCTGTCGAGCGAGCAGAGCGAGCGTGTGCTGGGCATGGCGCGGCTGGT
CGGGCAGGTCCAGGCGCTGGTGGAAAGCTCGGGCGATCCGCGCGGTTTCAGCGCGGCGCAGTGGGTGGCGCAGTGGCTGG
AGCAGCCTTCGCCGGCGCTGGGCGGGCGCCGCCCCGCTGAGCTGATGGATACGCTCGCCGGCCAGCGTATCGTTTCCGAC
CTGGTGGCCAGGATGCAGAGCGGGGCGTACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4KPF4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4KN77

References