Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3164322..3164961 Replicon chromosome
Accession NC_008313
Organism Ralstonia eutropha H16

Toxin (Protein)


Gene name vapC Uniprot ID Q0K7L6
Locus tag H16_RS14600 Protein ID WP_011615916.1
Coordinates 3164545..3164961 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R7XDA2
Locus tag H16_RS14595 Protein ID WP_010813840.1
Coordinates 3164322..3164558 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H16_RS14580 3159940..3161358 + 1419 WP_010813837.1 argininosuccinate lyase -
H16_RS14585 3161648..3162250 + 603 WP_011615914.1 TRAP transporter small permease subunit -
H16_RS14590 3162263..3163978 + 1716 WP_010813839.1 TRAP transporter large permease subunit -
H16_RS14595 3164322..3164558 + 237 WP_010813840.1 plasmid stability protein StbC Antitoxin
H16_RS14600 3164545..3164961 + 417 WP_011615916.1 type II toxin-antitoxin system VapC family toxin Toxin
H16_RS14605 3165030..3167303 - 2274 WP_011615917.1 arginine/lysine/ornithine decarboxylase -
H16_RS14610 3167454..3168020 - 567 WP_010813843.1 dCTP deaminase -
H16_RS14615 3168117..3168947 - 831 WP_010813844.1 formate dehydrogenase accessory sulfurtransferase FdhD -
H16_RS14620 3169011..3169400 - 390 WP_011615918.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15333.56 Da        Isoelectric Point: 6.7296

>T21674 WP_011615916.1 NC_008313:3164545-3164961 [Cupriavidus necator H16]
VYLIDTNVISETRKRERANPGVRAFFRQAAREGAALYLSALTVGELQRGVALIRHRGDTAQAELLEQWLATVLEDFGRLV
LPVDADVAQVWGQLRAPRPEHALDKFIAATALIHDLTIVTRNVEDFRGTGAMLLNPFT

Download         Length: 417 bp

>T21674 NC_008313:3164545-3164961 [Cupriavidus necator H16]
GTGTATTTGATTGATACCAACGTCATCAGCGAAACGCGCAAGCGCGAGCGCGCCAACCCCGGCGTGCGCGCGTTCTTCCG
GCAGGCGGCGCGGGAAGGTGCCGCGCTCTACCTGTCGGCGCTGACCGTGGGCGAGCTCCAGCGTGGCGTAGCGCTGATCC
GCCATCGCGGCGATACGGCGCAGGCCGAGCTGCTGGAGCAATGGCTGGCGACCGTGCTGGAGGATTTTGGCCGGCTGGTG
TTGCCGGTCGATGCCGACGTCGCCCAGGTCTGGGGCCAGCTGCGCGCGCCGCGGCCTGAGCACGCGCTGGACAAGTTCAT
TGCCGCCACCGCGCTGATCCATGACCTGACCATTGTCACGCGCAATGTTGAGGATTTCCGCGGCACGGGCGCGATGCTGC
TGAATCCGTTCACCTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8508.59 Da        Isoelectric Point: 5.8236

>AT21674 WP_010813840.1 NC_008313:3164322-3164558 [Cupriavidus necator H16]
MATLLVRGIDESLVQRLRERAVANGRSAEAEHRAILAQALGGTRRRSLAEVLASIPDVGQDADFERIQNPGEAPRVFD

Download         Length: 237 bp

>AT21674 NC_008313:3164322-3164558 [Cupriavidus necator H16]
ATGGCAACACTACTCGTTCGTGGCATCGATGAATCCCTGGTCCAGCGCCTGCGCGAGCGGGCCGTCGCCAACGGCCGCAG
CGCCGAGGCCGAGCACCGCGCCATCCTGGCGCAGGCGCTGGGCGGCACGCGCCGGCGCAGCCTGGCCGAGGTGCTGGCCA
GCATCCCGGACGTCGGGCAAGACGCCGACTTCGAGCGGATCCAGAATCCAGGCGAGGCGCCGCGTGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4KI19

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4KI67

References