Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4289989..4290627 Replicon chromosome
Accession NZ_CP083530
Organism Escherichia coli strain elppa2

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag K9U05_RS20185 Protein ID WP_000813794.1
Coordinates 4289989..4290165 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K9U05_RS20190 Protein ID WP_001270286.1
Coordinates 4290211..4290627 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U05_RS20165 (4285611) 4285611..4286783 - 1173 WP_022645663.1 BenE family transporter YdcO -
K9U05_RS20170 (4286875) 4286875..4287411 + 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
K9U05_RS20175 (4287484) 4287484..4289445 + 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
K9U05_RS20180 (4289537) 4289537..4289767 - 231 WP_000491567.1 DUF2554 family protein -
K9U05_RS20185 (4289989) 4289989..4290165 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
K9U05_RS20190 (4290211) 4290211..4290627 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
K9U05_RS20195 (4290706) 4290706..4292112 + 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
K9U05_RS20200 (4292357) 4292357..4293502 + 1146 WP_000047466.1 ABC transporter substrate-binding protein -
K9U05_RS20205 (4293520) 4293520..4294533 + 1014 WP_022645666.1 ABC transporter ATP-binding protein -
K9U05_RS20210 (4294534) 4294534..4295475 + 942 WP_228612523.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T216738 WP_000813794.1 NZ_CP083530:4289989-4290165 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T216738 NZ_CP113257:2503735-2504112 [Stutzerimonas frequens]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT216738 WP_001270286.1 NZ_CP083530:4290211-4290627 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT216738 NZ_CP113257:2504093-2504428 [Stutzerimonas frequens]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References