Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2499015..2499610 Replicon chromosome
Accession NZ_CP083530
Organism Escherichia coli strain elppa2

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag K9U05_RS11780 Protein ID WP_228611784.1
Coordinates 2499260..2499610 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag K9U05_RS11775 Protein ID WP_228611781.1
Coordinates 2499015..2499266 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U05_RS11765 (2494680) 2494680..2498459 + 3780 Protein_2284 autotransporter assembly complex protein TamB -
K9U05_RS11770 (2498462) 2498462..2498803 + 342 WP_228611779.1 gamma-glutamylcyclotransferase -
K9U05_RS11775 (2499015) 2499015..2499266 + 252 WP_228611781.1 type II toxin-antitoxin system ChpS family antitoxin Antitoxin
K9U05_RS11780 (2499260) 2499260..2499610 + 351 WP_228611784.1 endoribonuclease toxin ChpB Toxin
K9U05_RS11785 (2499689) 2499689..2500219 - 531 WP_000055075.1 inorganic diphosphatase -
K9U05_RS11790 (2500529) 2500529..2501485 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
K9U05_RS11795 (2501618) 2501618..2503120 + 1503 WP_022646474.1 sugar ABC transporter ATP-binding protein -
K9U05_RS11800 (2503134) 2503134..2504156 + 1023 WP_228611786.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12509.47 Da        Isoelectric Point: 5.6998

>T216725 WP_228611784.1 NZ_CP083530:2499260-2499610 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASSYEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T216725 NZ_CP113242:221950-222249 [Vibrio sp. gvc]
ATGAAACCATTTAATCTTACTGTCGCCGCGAAAGCCGACTTACGGGATATTGCTTTATTCACTCAACGCCGATGGGGAAA
AGAGCAGCGAAATATTTATTTAAAGCAGTTCGATGACTCATTTTGGCTTTTAGCGGAAAATCCTGACATCGGTAAATCAT
GCGATGAAATCCGAGAGGGCTACAGAAAATTCCCCCAAGGTAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTAATTCGAATTCTTCATAAGAGCATGGATGTAAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9347.68 Da        Isoelectric Point: 4.6509

>AT216725 WP_228611781.1 NZ_CP083530:2499015-2499266 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRLGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT216725 NZ_CP113242:221711-221953 [Vibrio sp. gvc]
ATGGCTAAAAACACAAGTATCACTCTTGGTGACCACTTCGATGGCTTTATTGCAAGCCAAATACAACGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCTCTGCGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TTGTTGAAGGTGAGCAAAGTGGTGACGTTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References