Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 896237..896891 Replicon chromosome
Accession NZ_CP083530
Organism Escherichia coli strain elppa2

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag K9U05_RS04120 Protein ID WP_000244781.1
Coordinates 896237..896644 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag K9U05_RS04125 Protein ID WP_000354046.1
Coordinates 896625..896891 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U05_RS04100 (892194) 892194..893927 - 1734 Protein_798 single-stranded-DNA-specific exonuclease RecJ -
K9U05_RS04105 (893933) 893933..894643 - 711 WP_077516663.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9U05_RS04110 (894668) 894668..895564 - 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
K9U05_RS04115 (895676) 895676..896197 + 522 WP_032303736.1 flavodoxin FldB -
K9U05_RS04120 (896237) 896237..896644 - 408 WP_000244781.1 protein YgfX Toxin
K9U05_RS04125 (896625) 896625..896891 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
K9U05_RS04130 (897134) 897134..898114 + 981 WP_077516665.1 tRNA-modifying protein YgfZ -
K9U05_RS04135 (898191) 898191..898850 - 660 WP_000250269.1 hemolysin III family protein -
K9U05_RS04140 (899014) 899014..899325 - 312 WP_077516667.1 N(4)-acetylcytidine aminohydrolase -
K9U05_RS04145 (899370) 899370..900803 + 1434 WP_136698981.1 6-phospho-beta-glucosidase BglA -
K9U05_RS04150 (900851) 900851..901600 - 750 WP_209319277.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T216715 WP_000244781.1 NZ_CP083530:c896644-896237 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T216715 NZ_CP113231:2498134-2498241 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT216715 WP_000354046.1 NZ_CP083530:c896891-896625 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216715 NZ_CP113231:c2498318-2498258 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References