Detailed information of TA system TA021670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 204061..204701
• Replicon: chromosome
• Accession: NC_008278
• Organism: Frankia alni ACN14a

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q0RU60
• Locus tag: FRAAL_RS00945
• Protein ID: WP_011601465.1
• Coordinates: 204061..204468 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FRAAL_RS00950
• Protein ID: WP_011601466.1
• Coordinates: 204465..204701 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FRAAL_RS00930	200166..201338	+	1173	WP_157891943.1	hypothetical protein	-
FRAAL_RS00935	201379..202896	+	1518	WP_011601463.1	sugar ABC transporter ATP-binding protein	-
FRAAL_RS00940	202893..203915	+	1023	WP_011601464.1	ABC transporter permease	-
FRAAL_RS00945	204061..204468	-	408	WP_011601465.1	type II toxin-antitoxin system VapC family toxin	Toxin
FRAAL_RS00950	204465..204701	-	237	WP_011601466.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FRAAL_RS00955	205524..206102	+	579	WP_011601469.1	hypothetical protein	-
FRAAL_RS00960	206279..206485	+	207	WP_041938635.1	hypothetical protein	-
FRAAL_RS31110	206485..206708	+	224	Protein_176	type II toxin-antitoxin system HicA family toxin	-
FRAAL_RS00965	207229..208632	+	1404	WP_011601473.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

• SpoVT-AbrB domain (4-43)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14047.04 Da
• Isoelectric Point: 7.5232

>T21670 WP_011601465.1 NC_008278:c204468-204061 [Frankia alni ACN14a]
VTIAVDTSVAIPLLVRSHQHHTDVARWWDGQQLTLSGHALAETYSVLTRLPGDARLSGPDAARLLDARFTAPLALSGPPA
QEIHTTLSQLGIAGGAVYDGLVALAAKAHGLALATRDARARGTYDAVGVKLILVG

Nucleotide

• Length: 408 bp

>T21670 NC_008278:c204468-204061 [Frankia alni ACN14a]
GTGACCATTGCCGTCGACACAAGCGTCGCCATTCCTCTGCTTGTCCGCTCACATCAACATCACACGGACGTAGCGCGATG
GTGGGACGGACAGCAGCTCACGCTGAGTGGGCACGCCCTGGCGGAGACCTACTCGGTACTCACCAGGTTGCCGGGCGACG
CCCGGCTGTCCGGGCCGGACGCCGCACGCCTGCTCGACGCGAGGTTCACGGCGCCGCTGGCGCTGAGCGGCCCGCCCGCC
CAGGAAATCCACACGACCCTGAGCCAACTCGGCATCGCCGGGGGCGCCGTGTATGACGGGCTGGTGGCGCTCGCCGCCAA
AGCGCATGGCCTGGCCCTCGCGACAAGGGATGCACGCGCGCGTGGAACCTATGATGCGGTCGGAGTCAAGCTGATTCTGG
TCGGATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8100.33 Da
• Isoelectric Point: 4.4116

>AT21670 WP_011601466.1 NC_008278:c204701-204465 [Frankia alni ACN14a]
MEAVVDQAGRIVLPKFIRDALGLLPGTKVDISPYGAGVQVVPAGRTARLVEENGVLVSAGDTPVDDDVLFGLIDAGRK

Nucleotide

• Length: 237 bp

>AT21670 NC_008278:c204701-204465 [Frankia alni ACN14a]
ATGGAAGCTGTTGTGGATCAGGCGGGCCGAATCGTGCTGCCCAAGTTCATCCGCGACGCGCTGGGCCTACTCCCGGGCAC
GAAGGTGGACATCTCGCCTTACGGGGCTGGTGTGCAGGTCGTGCCAGCCGGCAGGACCGCGCGCCTCGTCGAGGAGAACG
GCGTGCTCGTGTCGGCCGGCGACACGCCTGTCGATGACGATGTACTGTTCGGCCTCATCGACGCGGGACGCAAGTGA

Structures

Toxin

• AlphaFold DB: Q0RU60